Immunoglobulin D amyloidosis: A distinct entity

Morie A. Gertz, Francis K. Buadi, Suzanne R. Hayman, David Dingli, Angela Dispenzieri, Philip R. Greipp, Shaji K. Kumar, Martha Q. Lacy, John A. Lust, Nelson Leung, S. Vincent Rajkumar, Stephen J. Russell, Steven R. Zeldenrust, Joseph R. Mikhael, Vivek Roy, Robert A. Kyle

Research output: Contribution to journalArticlepeer-review

12 Scopus citations


IgD monoclonal gammopathies are uncommon. They are seen rarely as a monoclonal gammopathy of undetermined significance and are present in 1%-2% of patients with multiple myeloma. In light-chain amyloidosis, IgD monoclonal proteins are found in ap-proximately 1% of patients. When an IgD monoclonal protein is found, amyloidosis is often omitted from the differential diagnosis. In the present study, we reviewed the natural history of IgD-associated amyloidosis among 53 patients seen over 41 years. The distribution of clinical syndromes suggests that these patients have a lower frequency of renal and cardiac involvement. The overall survival of these patients does not appear to be different from that of patients who have light-chain amyloidosis associated with another monoclonal protein.

Original languageEnglish (US)
Pages (from-to)44-48
Number of pages5
Issue number1
StatePublished - Jan 5 2012

ASJC Scopus subject areas

  • Biochemistry
  • Immunology
  • Hematology
  • Cell Biology


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