TY - JOUR
T1 - Immune response gene products (Ia antigens) on glial and endothelial cells in virus-induced demyelination
AU - Rodriguez, M.
AU - Pierce, M. L.
AU - Howie, E. A.
N1 - Copyright:
Copyright 2004 Elsevier B.V., All rights reserved.
PY - 1987
Y1 - 1987
N2 - Theiler's murine encephalomyelitis virus induced central nervous system demyelination in susceptible strains of mice with s, q, v, p, and f H-2D alleles. We used immunoelectron microscopy to look for differential production of class I immune response gene products (Ia) within astrocytes, oligodendrocytes, microglia, and endothelial cells. Spinal cord sections from susceptible mice (B10.S and B10.ASR2) showed increased content of Ia in glial and endothelial cells. In contrast, resistant mice [B10.S(9R)] showed minimal Ia production within the CNS. The findings indicate an important role of class II immune response products on glial cells during demyelination after virus infection.
AB - Theiler's murine encephalomyelitis virus induced central nervous system demyelination in susceptible strains of mice with s, q, v, p, and f H-2D alleles. We used immunoelectron microscopy to look for differential production of class I immune response gene products (Ia) within astrocytes, oligodendrocytes, microglia, and endothelial cells. Spinal cord sections from susceptible mice (B10.S and B10.ASR2) showed increased content of Ia in glial and endothelial cells. In contrast, resistant mice [B10.S(9R)] showed minimal Ia production within the CNS. The findings indicate an important role of class II immune response products on glial cells during demyelination after virus infection.
UR - http://www.scopus.com/inward/record.url?scp=0023234382&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=0023234382&partnerID=8YFLogxK
M3 - Article
C2 - 3471814
AN - SCOPUS:0023234382
SN - 0022-1767
VL - 138
SP - 3438
EP - 3442
JO - Journal of Immunology
JF - Journal of Immunology
IS - 10
ER -