TY - JOUR
T1 - Immune-related conditions and immune-modulating medications as risk factors for non-Hodgkin's lymphoma
T2 - A case-control study
AU - Engels, Eric A.
AU - Cerhan, James R.
AU - Linet, Martha S.
AU - Cozen, Wendy
AU - Colt, Joanne S.
AU - Davis, Scott
AU - Gridley, Gloria
AU - Severson, Richard K.
AU - Hartge, Patricia
N1 - Funding Information:
The authors gratefully acknowledge the contributions of the SEER centers of Detroit, Iowa, Los Angeles, and Seattle for rapid identification of cases; the Centers for Medicare and Medicaid Services for selection of older controls; Carol Haines (Westat, Rockville, Maryland) for development of study materials and procedures, selection of younger controls, and study coordination; Peter Hui and Michael Stagner (Information Management Services, Silver Spring, Maryland) for computer programming support; and Geoffrey Tobias (National Cancer Institute) for research assistance. Conflict of interest: none declared.
PY - 2005/12
Y1 - 2005/12
N2 - In immunosuppressed or autoimmune disease states, disordered immune responses may lead to non-Hodgkin's lymphoma (NHL). In a US population-based case-control study of NHL (1998-2000), the authors collected personal histories of immune-related conditions and use of immune-modulating therapies as well as family histories of autoimmune conditions. The study included 1,321 NHL cases and 1,057 controls; only half received some questionnaire components. NHL was associated with Sjögren's syndrome (odds ratio (OR) = 13, 95% confidence interval (CI): 1.7, 100) and lupus (OR = 4.2, 95% CI: 1.2, 15). Two specific NHL subtypes were strongly associated with Sjögren's syndrome: salivary gland (OR = 290, 95% CI: 33, 2600) and marginal zone (OR = 75, 95% CI: 9.1, 610). NHL was less convincingly associated with receipt of an organ transplant (OR = 2.0, 95% CI: 0.4, 11). Other autoimmune conditions were too rare to evaluate or not associated with NHL. Corticosteroid use was unrelated to NHL (OR = 1.0, 95% CI: 0.8, 1.2), but methotrexate use was marginally associated (OR = 2.3, 95% CI: 0.7, 7.5). Family history of dermatomyositis was associated with NHL (7 cases vs. 0 controls, OR = infinite; two-sided p = 0.02), but dermatomyositis was absent in cases themselves. Family history of remaining conditions was unrelated to NHL. Results suggest that disordered immunity in some immune-related conditions can lead to NHL.
AB - In immunosuppressed or autoimmune disease states, disordered immune responses may lead to non-Hodgkin's lymphoma (NHL). In a US population-based case-control study of NHL (1998-2000), the authors collected personal histories of immune-related conditions and use of immune-modulating therapies as well as family histories of autoimmune conditions. The study included 1,321 NHL cases and 1,057 controls; only half received some questionnaire components. NHL was associated with Sjögren's syndrome (odds ratio (OR) = 13, 95% confidence interval (CI): 1.7, 100) and lupus (OR = 4.2, 95% CI: 1.2, 15). Two specific NHL subtypes were strongly associated with Sjögren's syndrome: salivary gland (OR = 290, 95% CI: 33, 2600) and marginal zone (OR = 75, 95% CI: 9.1, 610). NHL was less convincingly associated with receipt of an organ transplant (OR = 2.0, 95% CI: 0.4, 11). Other autoimmune conditions were too rare to evaluate or not associated with NHL. Corticosteroid use was unrelated to NHL (OR = 1.0, 95% CI: 0.8, 1.2), but methotrexate use was marginally associated (OR = 2.3, 95% CI: 0.7, 7.5). Family history of dermatomyositis was associated with NHL (7 cases vs. 0 controls, OR = infinite; two-sided p = 0.02), but dermatomyositis was absent in cases themselves. Family history of remaining conditions was unrelated to NHL. Results suggest that disordered immunity in some immune-related conditions can lead to NHL.
KW - Autoimmune diseases
KW - Case-control studies
KW - Immunosuppression
KW - Lymphoma, non-Hodgkin
KW - Methotrexate
KW - Organ transplantation
KW - Risk factors
KW - Sjogren's syndrome
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U2 - 10.1093/aje/kwi341
DO - 10.1093/aje/kwi341
M3 - Article
C2 - 16251389
AN - SCOPUS:28944450053
SN - 0002-9262
VL - 162
SP - 1153
EP - 1161
JO - American journal of epidemiology
JF - American journal of epidemiology
IS - 12
ER -