Immune-complex deposits in "pauci-immune" glomerulonephritis: A case report and brief review of recent literature

Mireille El-Ters; Umadevi Muthyala; Marie D. Philipneri; Fadi A. Hussein; Krista L. Lentine

doi:10.5114/aoms.2010.14479

Immune-complex deposits in "pauci-immune" glomerulonephritis: A case report and brief review of recent literature

Mireille El-Ters, Umadevi Muthyala, Marie D. Philipneri, Fadi A. Hussein, Krista L. Lentine

Nephrology and Hypertension

Research output: Contribution to journal › Article › peer-review

4 Scopus citations

Abstract

Anti-neutrophil cytoplasmic antibody (ANCA)-associated glomerulonephritis is considered a "pauci-immune" disease, characterized by absent or mild glomerular tuft staining for immunoglobulin and/or complement. We describe a 72-year-old man with progressive renal failure over five months who was found to have P-ANCA associated crescentic glomerulonephritis. Renal biopsy also revealed immunofluorescence staining for Immunoglobulin G and C3. Treatment comprised corticosteroids, cyclophosphamide, and plasmapheresis but unfortunately kidney function did not recover, likely due to substantial interstitial fibrosis at diagnosis. This case illustrates that serologic evaluation for ANCAs should not be discounted when immune deposits are present. Prompt diagnosis is warranted.

Original language	English (US)
Pages (from-to)	633-637
Number of pages	5
Journal	Archives of Medical Science
Volume	6
Issue number	4
DOIs	https://doi.org/10.5114/aoms.2010.14479
State	Published - Aug 2010

Keywords

Anti-neutrophil cytoplasmic antibodies
Glomerulonephritis
Immune deposits

ASJC Scopus subject areas

Medicine(all)

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10.5114/aoms.2010.14479

Cite this

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Immune-complex deposits in "pauci-immune" glomerulonephritis: A case report and brief review of recent literature

Abstract

Keywords

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