Imaging of cerebral activation at 1.5 T: Otimizing a technique for conventional hardware

Richard M. Thompson, Clifford R. Jack, Kim Butts, Dennis P. Hanson, Stephen J. Riederer, Richard L. Ehman, Roger W. Hynes, Nicholas J. Hangiandreou

Research output: Contribution to journalArticlepeer-review

21 Scopus citations


PURPOSE: To empirically optimize a two-dimensional magnetic resonance (MR) imaging technique for detecting changes in signal intensity during cerebral activation with a standard clinical imager. MATERIALS AND METHODS: Visual activation experiments were performed while imaging parameters were manipulated in a serial fashion, to test their effect on the percentage change in signal intensity (PCSI). The parameters tested were section thickness, echo time (TE), field of view (FOV), flip angle, radio-frequency (RF) spoiling, number of readout points, and number of signals averaged. RESULTS: The PCSI for visual activation experiments was typically in the 1%-5% range. The best results were achieved with a small section thickness, long TE, and large FOV. Variations in other acquisition parameters had a negligible influence on the PCSI. CONCLUSION: Good results can be obtained at functional MR imaging with standard 1.5-T hardware. Markedly improved results can be obtained by optimizing several key variables, namely, section thickness, TE, and FOV.

Original languageEnglish (US)
Pages (from-to)873-877
Number of pages5
Issue number3
StatePublished - Mar 1994


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ASJC Scopus subject areas

  • Radiology Nuclear Medicine and imaging


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