TY - JOUR
T1 - Ileal pouch-anal anastomosis in patients with colorectal cancer
T2 - Long- term functional and oncologic outcomes
AU - Radice, Elisabetta
AU - Nelson, Heidi
AU - Devine, Richard M.
AU - Dozois, Roger R.
AU - Nivatvongs, Santhat
AU - Pemberton, John H.
AU - Wolff, Bruce G.
AU - Fozard, J. Basil J.
AU - Ilstrup, Duane
PY - 1998/1
Y1 - 1998/1
N2 - When colorectal cancer complicates chronic ulcerative colitis or familial adenomatous polyposis, the role of ileal pouch-anal anastomosis is uncertain because of concerns that the procedure may compromise oncologic therapy and that oncologic therapy may compromise ileal pouch-anal anastomosis function. AIM: This study was undertaken to investigate the impact both of ileal pouch-anal anastomosis on cancer outcomes and of cancer treatments on ileal pouch-anal anastomosis function. PATIENTS AND METHODS: Of 1,616 patients undergoing ileal pouch-anal anastomosis for chronic ulcerative colitis or familial adenomatous polyposis (1981-1994), 77 patients were identified with adenocarcinoma of the colon (56), rectum (17), or both (4). Data were obtained from an ileal pouch-anal anastomosis registry, case notes, and postal and telephone surveys. RESULTS: Mean age of the 77 index patients was 37 (range, 13-60) years. Stage distribution was as follows: Stage 0, 9; Stage I, 31; Stage II, 15; Stage III, 22 patients. Twelve patients died with systemic disease (6 with a local component) after a mean follow-up of 6 (range, 2-15) years. Twenty-two patients received adjuvant therapy (chemotherapy, 16; radiotherapy, 2; both, 4 patients). Chemotherapy complications requiring dose reduction or interruption occurred in three (15 percent) patients. One patient developed radiation enteritis (17 percent). Pouch failure occurred in 16 percent of cancer patients, compared with 7 percent for the overall registry. There were no differences between cancer and non-cancer groups in operative complications, median stool frequency, incontinence, pad usage, or pouchitis. CONCLUSIONS: Although pouch failure is more common, ileal pouch-anal anastomosis can he performed in the setting of colorectal cancer without significant impact on oncologic outcome or long- term ileal pouch-anal anastomosis function.
AB - When colorectal cancer complicates chronic ulcerative colitis or familial adenomatous polyposis, the role of ileal pouch-anal anastomosis is uncertain because of concerns that the procedure may compromise oncologic therapy and that oncologic therapy may compromise ileal pouch-anal anastomosis function. AIM: This study was undertaken to investigate the impact both of ileal pouch-anal anastomosis on cancer outcomes and of cancer treatments on ileal pouch-anal anastomosis function. PATIENTS AND METHODS: Of 1,616 patients undergoing ileal pouch-anal anastomosis for chronic ulcerative colitis or familial adenomatous polyposis (1981-1994), 77 patients were identified with adenocarcinoma of the colon (56), rectum (17), or both (4). Data were obtained from an ileal pouch-anal anastomosis registry, case notes, and postal and telephone surveys. RESULTS: Mean age of the 77 index patients was 37 (range, 13-60) years. Stage distribution was as follows: Stage 0, 9; Stage I, 31; Stage II, 15; Stage III, 22 patients. Twelve patients died with systemic disease (6 with a local component) after a mean follow-up of 6 (range, 2-15) years. Twenty-two patients received adjuvant therapy (chemotherapy, 16; radiotherapy, 2; both, 4 patients). Chemotherapy complications requiring dose reduction or interruption occurred in three (15 percent) patients. One patient developed radiation enteritis (17 percent). Pouch failure occurred in 16 percent of cancer patients, compared with 7 percent for the overall registry. There were no differences between cancer and non-cancer groups in operative complications, median stool frequency, incontinence, pad usage, or pouchitis. CONCLUSIONS: Although pouch failure is more common, ileal pouch-anal anastomosis can he performed in the setting of colorectal cancer without significant impact on oncologic outcome or long- term ileal pouch-anal anastomosis function.
KW - Cancer
KW - Familial adenomatous polyposis
KW - Functional outcome
KW - Ileal pouch-anal anastomosis
KW - Ileoanal
KW - Ulcerative colitis
UR - http://www.scopus.com/inward/record.url?scp=0031983403&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=0031983403&partnerID=8YFLogxK
U2 - 10.1007/BF02236889
DO - 10.1007/BF02236889
M3 - Article
C2 - 9510305
AN - SCOPUS:0031983403
SN - 0012-3706
VL - 41
SP - 11
EP - 17
JO - Diseases of the colon and rectum
JF - Diseases of the colon and rectum
IS - 1
ER -