IL-10 Inhibits FcεRI Expression in Mouse Mast Cells

Sheila R. Gillespie, Randall R. DeMartino, Jingfang Zhu, Hey Jin Chong, Carlos Ramirez, Christopher P. Shelburne, L. Andrew Bouton, Daniel P. Bailey, Anita Gharse, Paria Mirmonsef, Sandra Odom, Gregorio Gomez, Juan Rivera, Krista Fischer-Stenger, John J. Ryan

Research output: Contribution to journalArticlepeer-review

54 Scopus citations


FcεRI expression and function is a central aspect of allergic disease. Using bone marrow-derived mouse mast cell populations, we have previously shown that the Th2 cytokine IL-4 inhibits FcεRI expression and function. In the current study we show that the Th2 cytokine IL-10 has similar regulatory properties, and that it augments the inhibitory effects of IL-4. FcεRI down-regulation was functionally significant, as it diminished inflammatory cytokine production and IgE-mediated FcεRI up-regulation. IL-10 and IL-4 reduced FcεRI β protein expression without altering the α or γ subunits. The ability of IL-4 and IL-10 to alter FcεRI expression by targeting the β-chain, a critical receptor subunit known to modulate receptor expression and signaling, suggests the presence of a Th2 cytokine-mediated homeostatic network that could serve to both initiate and limit mast cell effector function.

Original languageEnglish (US)
Pages (from-to)3181-3188
Number of pages8
JournalJournal of Immunology
Issue number5
StatePublished - Mar 1 2004

ASJC Scopus subject areas

  • Immunology and Allergy
  • Immunology


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