TY - JOUR
T1 - IL-1 receptor antagonist protects against placental and neurodevelopmental defects induced by maternal inflammation
AU - Girard, Sylvie
AU - Tremblay, Luc
AU - Lepage, Martin
AU - Sébire, Guillaume
PY - 2010/4/1
Y1 - 2010/4/1
N2 - The precise role of maternal bacterial infection and inflammation occurring at the end of gestation is a controversial matter. Although it is recognized as an independent risk factor for neurodevelopmental diseases such as cerebral palsy, mental deficiency, and autism, it remains unclear whether it is causal or simply associated with the diseases. In this study, we demonstrate that IL-1 plays a key role in mediating severe placental damage and neurodevelopmental anomalies in offspring. Our results show that end of gestation exposure of pregnant rats to systemic microbial product (LPS) triggers placental inflammation and massive cell death, fetal mortality, and both forebrain white matter and motor behavioral alterations in the offspring. All these effects are alleviated by the coadministration of IL-1 receptor antagonist with LPS, suggesting a possible protective treatment against human placental and fetal brain damage.
AB - The precise role of maternal bacterial infection and inflammation occurring at the end of gestation is a controversial matter. Although it is recognized as an independent risk factor for neurodevelopmental diseases such as cerebral palsy, mental deficiency, and autism, it remains unclear whether it is causal or simply associated with the diseases. In this study, we demonstrate that IL-1 plays a key role in mediating severe placental damage and neurodevelopmental anomalies in offspring. Our results show that end of gestation exposure of pregnant rats to systemic microbial product (LPS) triggers placental inflammation and massive cell death, fetal mortality, and both forebrain white matter and motor behavioral alterations in the offspring. All these effects are alleviated by the coadministration of IL-1 receptor antagonist with LPS, suggesting a possible protective treatment against human placental and fetal brain damage.
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U2 - 10.4049/jimmunol.0903349
DO - 10.4049/jimmunol.0903349
M3 - Article
C2 - 20181892
AN - SCOPUS:77951642214
SN - 0022-1767
VL - 184
SP - 3997
EP - 4005
JO - Journal of Immunology
JF - Journal of Immunology
IS - 7
ER -