TY - JOUR
T1 - IGVL gene region usage correlates with distinct clinical presentation in IgM vs non-IgM light chain amyloidosis
AU - Sidana, Surbhi
AU - Dasari, Surendra
AU - Kourelis, Taxiarchis V.
AU - Dispenzieri, Angela
AU - Murray, David L.
AU - King, Rebecca L.
AU - McPhail, Ellen D.
AU - Ramirez-Alvarado, Marina
AU - Kumar, Shaji K.
AU - Gertz, Morie A.
N1 - Publisher Copyright:
© 2021 by The American Society of Hematology
PY - 2021/4/27
Y1 - 2021/4/27
N2 - Patients with immunoglobulin M (IgM) light chain (AL) amyloidosis have a distinct clinical presentation compared with those with non-IgM amyloidosis. We hypothesized that differential immunoglobulin light-chain variable region (IGVL) gene usage may explain the differences in organ involvement, because IGVL usage correlates with organ tropism. IGVL usage was evaluated by mass spectrometry of amyloid deposits (IgM, n 5 45; non-IgM, n 5 391) and differed across the 2 groups. In the l family, LV2-08 (13% vs 2%; P, .001) and LV2-14 (36% vs 10%; P, .001) usage was more common in IgM vs non-IgM amyloidosis, whereas LV1-44 (0% vs 10%; P 5 .02) and LV6-57 (2% vs 18%; P 5 .004) usage was less common. In the k family, there was a trend toward higher KV4-01 (11% vs 4%; P 5 .06) usage in IgM amyloidosis. IGVL usage correlated with disease characteristics/organ tropism. LV2-14 (more common in IgM amyloidosis) has historically been associated with peripheral nerve involvement and lower light chain burden, which were more frequent in IgM amyloidosis. LV1-44 (less common in IgM), associated with cardiac involvement, was less frequent in IgM patients. LV6-57 (less common in IgM) is associated with t(11;14), which was less frequent in IgM patients. In conclusion, IGVL gene usage differs in patients with IgM vs non-IgM amyloidosis and may explain the distinct clinical presentation.
AB - Patients with immunoglobulin M (IgM) light chain (AL) amyloidosis have a distinct clinical presentation compared with those with non-IgM amyloidosis. We hypothesized that differential immunoglobulin light-chain variable region (IGVL) gene usage may explain the differences in organ involvement, because IGVL usage correlates with organ tropism. IGVL usage was evaluated by mass spectrometry of amyloid deposits (IgM, n 5 45; non-IgM, n 5 391) and differed across the 2 groups. In the l family, LV2-08 (13% vs 2%; P, .001) and LV2-14 (36% vs 10%; P, .001) usage was more common in IgM vs non-IgM amyloidosis, whereas LV1-44 (0% vs 10%; P 5 .02) and LV6-57 (2% vs 18%; P 5 .004) usage was less common. In the k family, there was a trend toward higher KV4-01 (11% vs 4%; P 5 .06) usage in IgM amyloidosis. IGVL usage correlated with disease characteristics/organ tropism. LV2-14 (more common in IgM amyloidosis) has historically been associated with peripheral nerve involvement and lower light chain burden, which were more frequent in IgM amyloidosis. LV1-44 (less common in IgM), associated with cardiac involvement, was less frequent in IgM patients. LV6-57 (less common in IgM) is associated with t(11;14), which was less frequent in IgM patients. In conclusion, IGVL gene usage differs in patients with IgM vs non-IgM amyloidosis and may explain the distinct clinical presentation.
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U2 - 10.1182/BLOODADVANCES.2020003671
DO - 10.1182/BLOODADVANCES.2020003671
M3 - Article
C2 - 33877297
AN - SCOPUS:85106301475
SN - 2473-9529
VL - 5
SP - 2101
EP - 2105
JO - Blood Advances
JF - Blood Advances
IS - 8
ER -