Identification of proteins in human substantia nigra

Efstathia Kitsou, Sheng Pan, Jian Peng Zhang, Min Shi, Aram Zabeti, Dennis W. Dickson, Roger Albin, Maria Gearing, Daniel T. Kashima, Yan Wang, Richard P. Beyer, Yong Zhou, Catherine Pan, W. Michael Caudle, Jing Zhang

Research output: Contribution to journalArticlepeer-review

27 Scopus citations


Characterization of the human brain proteome is a critical area of research. While examination of the human cortex has provided some insight, very little is known about the proteome of the human midbrain, which demonstrates substantial loss of dopaminergic neurons in the substantia nigra pars compacta (SNpc) in Parkinson's disease (PD). Therefore, characterization of this region is essential to a better understanding of the pathogenesis of PD. This dataset paper reports two separate studies, where human SNpc was collected from PD and control subjects and 1263 proteins were identified using MALDI-TOF/TOF as well as linear ion trap MS platforms. With gene ontology analysis, the proteins were categorized according to their biological processes, as well as cellular components. These data were also compared with previous proteomic characterization of the human frontal and temporal cortex, and cerebrospinal fluid to establish shared proteins of relevance. The present dataset is the most extensive survey of the human SNpc proteome, to date. Further characterization of the SNpc proteome will significantly facilitate our understanding of the function and expression of proteins involved in PD, as well as provide potential proteins that may be utilized as biomarkers.

Original languageEnglish (US)
Pages (from-to)776-782
Number of pages7
JournalProteomics - Clinical Applications
Issue number5
StatePublished - May 2008


  • Biomarkers
  • Cerebrospinal fluid
  • MS
  • Parkinson's disease
  • Substantia nigra pars compacta

ASJC Scopus subject areas

  • Clinical Biochemistry


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