Identification of a novel KMT2A/GIMAP8 gene fusion in a pediatric patient with acute undifferentiated leukemia

Holly E. Berg; Patrick R. Blackburn; Linda B. Baughn; Rhett P. Ketterling; Xinjie Xu; Patricia T. Greipp; Nicole L. Hoppman; James B. Smadbeck; George Vasmatzis; Min Shi; Kaaren K. Reichard; David S. Viswanatha; Dragan Jevremovic; George M. Maher; Jess F. Peterson

doi:10.1002/gcc.22902

Identification of a novel KMT2A/GIMAP8 gene fusion in a pediatric patient with acute undifferentiated leukemia

Holly E. Berg, Patrick R. Blackburn, Linda B. Baughn, Rhett P. Ketterling, Xinjie Xu, Patricia T. Greipp, Nicole L. Hoppman, James B. Smadbeck, George Vasmatzis, Min Shi, Kaaren K. Reichard, David S. Viswanatha, Dragan Jevremovic, George M. Maher, Jess F. Peterson

Research output: Contribution to journal › Article › peer-review

1 Scopus citations

Abstract

Acute undifferentiated leukemia (AUL) is a very rare hematologic neoplasm that expresses no markers specific for either myeloid or lymphoid lineages. While commonly observed in several acute leukemias, KMT2A rearrangements in AUL have been rarely reported in the literature. We report the third case to our knowledge of AUL harboring a KMT2A rearrangement. Furthermore, the KMT2A/GIMAP8 gene fusion identified in this case represents a novel KMT2A rearrangement.

Original language	English (US)
Pages (from-to)	108-111
Number of pages	4
Journal	Genes Chromosomes and Cancer
Volume	60
Issue number	2
DOIs	https://doi.org/10.1002/gcc.22902
State	Published - Feb 2021

Keywords

GIMAP8
KMT2A
acute undifferentiated leukemia
mate-pair sequencing
next-generation sequencing

ASJC Scopus subject areas

Genetics
Cancer Research

Access to Document

10.1002/gcc.22902

Cite this

Berg, H. E., Blackburn, P. R., Baughn, L. B., Ketterling, R. P., Xu, X., Greipp, P. T., Hoppman, N. L., Smadbeck, J. B., Vasmatzis, G., Shi, M., Reichard, K. K., Viswanatha, D. S., Jevremovic, D., Maher, G. M., & Peterson, J. F. (2021). Identification of a novel KMT2A/GIMAP8 gene fusion in a pediatric patient with acute undifferentiated leukemia. Genes Chromosomes and Cancer, 60(2), 108-111. https://doi.org/10.1002/gcc.22902

Berg, HE, Blackburn, PR, Baughn, LB, Ketterling, RP, Xu, X, Greipp, PT, Hoppman, NL, Smadbeck, JB , Vasmatzis, G, Shi, M, Reichard, KK, Viswanatha, DS, Jevremovic, D, Maher, GM & Peterson, JF 2021, 'Identification of a novel KMT2A/GIMAP8 gene fusion in a pediatric patient with acute undifferentiated leukemia', Genes Chromosomes and Cancer, vol. 60, no. 2, pp. 108-111. https://doi.org/10.1002/gcc.22902

@article{18bd2f2774d1438d99e26c06b5fe5774,

title = "Identification of a novel KMT2A/GIMAP8 gene fusion in a pediatric patient with acute undifferentiated leukemia",

abstract = "Acute undifferentiated leukemia (AUL) is a very rare hematologic neoplasm that expresses no markers specific for either myeloid or lymphoid lineages. While commonly observed in several acute leukemias, KMT2A rearrangements in AUL have been rarely reported in the literature. We report the third case to our knowledge of AUL harboring a KMT2A rearrangement. Furthermore, the KMT2A/GIMAP8 gene fusion identified in this case represents a novel KMT2A rearrangement.",

keywords = "GIMAP8, KMT2A, acute undifferentiated leukemia, mate-pair sequencing, next-generation sequencing",

author = "Berg, {Holly E.} and Blackburn, {Patrick R.} and Baughn, {Linda B.} and Ketterling, {Rhett P.} and Xinjie Xu and Greipp, {Patricia T.} and Hoppman, {Nicole L.} and Smadbeck, {James B.} and George Vasmatzis and Min Shi and Reichard, {Kaaren K.} and Viswanatha, {David S.} and Dragan Jevremovic and Maher, {George M.} and Peterson, {Jess F.}",

note = "Publisher Copyright: {\textcopyright} 2020 Wiley Periodicals LLC.",

year = "2021",

month = feb,

doi = "10.1002/gcc.22902",

language = "English (US)",

volume = "60",

pages = "108--111",

journal = "Genes Chromosomes and Cancer",

issn = "1045-2257",

publisher = "Wiley-Liss Inc.",

number = "2",

}

TY - JOUR

T1 - Identification of a novel KMT2A/GIMAP8 gene fusion in a pediatric patient with acute undifferentiated leukemia

AU - Berg, Holly E.

AU - Blackburn, Patrick R.

AU - Baughn, Linda B.

AU - Ketterling, Rhett P.

AU - Xu, Xinjie

AU - Greipp, Patricia T.

AU - Hoppman, Nicole L.

AU - Smadbeck, James B.

AU - Vasmatzis, George

AU - Shi, Min

AU - Reichard, Kaaren K.

AU - Viswanatha, David S.

AU - Jevremovic, Dragan

AU - Maher, George M.

AU - Peterson, Jess F.

PY - 2021/2

Y1 - 2021/2

N2 - Acute undifferentiated leukemia (AUL) is a very rare hematologic neoplasm that expresses no markers specific for either myeloid or lymphoid lineages. While commonly observed in several acute leukemias, KMT2A rearrangements in AUL have been rarely reported in the literature. We report the third case to our knowledge of AUL harboring a KMT2A rearrangement. Furthermore, the KMT2A/GIMAP8 gene fusion identified in this case represents a novel KMT2A rearrangement.

AB - Acute undifferentiated leukemia (AUL) is a very rare hematologic neoplasm that expresses no markers specific for either myeloid or lymphoid lineages. While commonly observed in several acute leukemias, KMT2A rearrangements in AUL have been rarely reported in the literature. We report the third case to our knowledge of AUL harboring a KMT2A rearrangement. Furthermore, the KMT2A/GIMAP8 gene fusion identified in this case represents a novel KMT2A rearrangement.

KW - GIMAP8

KW - KMT2A

KW - acute undifferentiated leukemia

KW - mate-pair sequencing

KW - next-generation sequencing

UR - http://www.scopus.com/inward/record.url?scp=85092935324&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=85092935324&partnerID=8YFLogxK

U2 - 10.1002/gcc.22902

DO - 10.1002/gcc.22902

M3 - Article

C2 - 33078871

AN - SCOPUS:85092935324

SN - 1045-2257

VL - 60

SP - 108

EP - 111

JO - Genes Chromosomes and Cancer

JF - Genes Chromosomes and Cancer

IS - 2

ER -

Identification of a novel KMT2A/GIMAP8 gene fusion in a pediatric patient with acute undifferentiated leukemia

Abstract

Keywords

ASJC Scopus subject areas

Access to Document

Other files and links

Fingerprint

Cite this