TY - JOUR
T1 - ICAM-1 expression determines malignant potential of cancer
AU - Roland, Christina L.
AU - Harken, Alden H.
AU - Sarr, Michael G.
AU - Barnett, Carlton C.
PY - 2007/6
Y1 - 2007/6
N2 - Hypothesis: Solid tumor cells bind to ICAM-1 on endothelial surfaces via MUC-1. Tumor binding to ICAM-1 auto-upregulates tumor ICAM-1 at the leading edge of the tumor and promotes release of chemoattractants for circulating macrophages, and circulating macrophages bind to tumor-expressed ICAM-1, invoking propagation of further chemokines and cytokines that recruit neutrophils. Tight adherence between cell surface ligands on neutrophils and tumor-expressed ICAM-1 activates neutrophils to degranulate, releasing elastases, which break down endovascular and endolymphatic barriers permitting transendothelial tumor cell migration. Consequently, tumor cell ICAM-1 expression dictates metastatic potential and metastatic potential determines cancer lethality.
AB - Hypothesis: Solid tumor cells bind to ICAM-1 on endothelial surfaces via MUC-1. Tumor binding to ICAM-1 auto-upregulates tumor ICAM-1 at the leading edge of the tumor and promotes release of chemoattractants for circulating macrophages, and circulating macrophages bind to tumor-expressed ICAM-1, invoking propagation of further chemokines and cytokines that recruit neutrophils. Tight adherence between cell surface ligands on neutrophils and tumor-expressed ICAM-1 activates neutrophils to degranulate, releasing elastases, which break down endovascular and endolymphatic barriers permitting transendothelial tumor cell migration. Consequently, tumor cell ICAM-1 expression dictates metastatic potential and metastatic potential determines cancer lethality.
UR - http://www.scopus.com/inward/record.url?scp=34249883065&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=34249883065&partnerID=8YFLogxK
U2 - 10.1016/j.surg.2007.01.016
DO - 10.1016/j.surg.2007.01.016
M3 - Article
C2 - 17560245
AN - SCOPUS:34249883065
SN - 0039-6060
VL - 141
SP - 705
EP - 707
JO - Surgery
JF - Surgery
IS - 6
ER -