Hypoxic-ischaemic brain injury (HIBI) after cardiopulmonary arrest

William D. Freeman, Michelle L. Biewend, Kevin M. Barrett

Research output: Contribution to journalArticlepeer-review

1 Scopus citations


Hypoxic-ischaemic brain injury (HIBI) is unfortunately a common complication after cardiopulmonary arrest (CPA) with devastating neurologic complications. Intensive care unit (ICU) management is initially aimed at cardiovascular stabilization and correction of the underlying cause of arrest such as ventricular fibrillation (VF), myocardial infarction from symptomatic coronary artery disease (CAD), or respiratory arrest. Once the patient is stabilized from a cardiac standpoint, growing evidence suggests that therapeutic hypothermia may provide cerebral neuroprotective benefit for VF-related CPA. Practical ICU evaluation and implementation of therapeutic hypothermia is discussed. Evaluation and management of HIBI-related autonomic disturbances or paroxysmal autonomic instability with dystonia (PAID) is discussed. Finally, we review the literature regarding neurological prognostication after cardiac arrest and the tests with highest specificity that can aid in the decision-making process.

Original languageEnglish (US)
Pages (from-to)261-276
Number of pages16
JournalCurrent Anaesthesia and Critical Care
Issue number5-6
StatePublished - 2007


  • Anoxic brain injury
  • Cardiac arrest
  • Hypoxic brain
  • Hypoxic brain injury
  • Injury

ASJC Scopus subject areas

  • Critical Care and Intensive Care Medicine
  • Anesthesiology and Pain Medicine


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