Hypoglossal nerve palsy: 245 cases

Amro M. Stino, Benn E. Smith, Mohamed Temkit, Srivan Nagi Reddy

Research output: Contribution to journalArticlepeer-review

14 Scopus citations


Introduction: Apart from a case series of 100 subjects in 1996 and several small cohorts, there have been no large retrospective series of cranial nerve XII (CN XII) palsy. Methods: From 1984 to 2014, 245 cases of CN XII palsy were identified via retrospective chart review using historical and exam findings that confirmed the diagnosis. In addition to clinical characteristics, univariate and multivariate models were investigated to predict neoplastic CN XII palsy. Results: Major etiologic categories included: postoperative (29.3%), idiopathic (15.1%), primary neoplastic (14.2%), metastatic malignancy (13.0%), inflammatory (7.3%), radiation (6.1%), and traumatic (4.1%). A multivariate model revealed male gender and a personal history of cancer as predictive of neoplastic CN XII palsy. Conclusions: The most frequent etiologies and disease categories of CN XII palsy were identified, and male gender and personal history of cancer were found to be predictive of a neoplastic cause of CN XII palsy. Muscle Nerve 54: 1050–1054, 2016.

Original languageEnglish (US)
Pages (from-to)1050-1054
Number of pages5
JournalMuscle and Nerve
Issue number6
StatePublished - Dec 1 2016


  • cranial nerve palsy
  • dysarthria
  • dysphagia
  • hypoglossal palsy
  • malignancy
  • multivariate model
  • risk factors

ASJC Scopus subject areas

  • Physiology
  • Clinical Neurology
  • Cellular and Molecular Neuroscience
  • Physiology (medical)


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