Hypertrophic Obstructive Cardiomyopathy: Discrepancy Between Hemodynamic Measurements in the Cardiac Laboratory and Operating Room Is to Be Expected

Juliano Lentz Carvalho, Elena Ashikhmina, Martin D. Abel, Jason K. Viehman, Brian D. Lahr, Jeffrey B. Geske, Hartzell V. Schaff

Research output: Contribution to journalArticlepeer-review


Objectives: It is not uncommon to observe some discrepancy in hemodynamic values characterizing left ventricular outflow tract (LVOT) obstruction preoperatively and in the operating room in patients with hypertrophic obstructive cardiomyopathy. Interpretation of this discrepancy can be challenging. To clarify the extent of the discrepancy, the authors compared hemodynamic variables in patients undergoing septal myectomy at the time of preoperative and intraoperative evaluation. Design: Retrospective study. Setting: Single academic medical center. Interventions: Medical records review, study group—173 patients. Measurements and Main Results: While there was no statistically significant difference in resting peak LVOT gradients by preoperative transthoracic echocardiography (TTE) compared to intraoperative transesophageal echocardiography (46 mmHg [19-87 mmHg] v 36 mmHg [16-71 mmHg], p = 0.231), the former were higher compared to direct needle-resting LVOT gradient measurements before myectomy (49 mmHg [19-88 mmHg] v 32 mmHg [14-67 mmHg], p = 0.0022). The prevalence of systolic anterior motion was high (94.6% v 91.6%, P = 1.000) both on pre- and intraoperative evaluation. The incidence of moderate/severe mitral was higher intraoperatively (p < 0.0001). Pulmonary artery systolic pressures measured by pulmonary artery catheter provided higher values compared to preoperative TTE estimate (39 mmHg [34-45 mmHg] v 34 mmHg [28-41 mmHg], p < 0.0001). Conclusions: Discrepancy between hemodynamic measurements in the cardiac laboratory and operating room is common and generally should not affect planned patients’ care. These changes in hemodynamics might be explained by preoperative fasting, anesthetic agents, volume shifts while supine, and positive-pressure ventilation, as well as the difference in measurement techniques.

Original languageEnglish (US)
Pages (from-to)422-428
Number of pages7
JournalJournal of Cardiothoracic and Vascular Anesthesia
Issue number2
StatePublished - Feb 2022


  • hypertrophic cardiomyopathy
  • myectomy
  • outflow tract obstruction
  • perioperative management

ASJC Scopus subject areas

  • Cardiology and Cardiovascular Medicine
  • Anesthesiology and Pain Medicine


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