TY - JOUR
T1 - Hypertension, a low ejection fraction and severe angiographic findings are associated with smooth muscle dysfunction in patients with coronary atherosclerosis
AU - Bae, Jang Ho
AU - Rihal, Charanjit S.
AU - Hyun, Dae Woo
AU - Park, Ki Rack
AU - Kwon, Taek Geun
AU - Yoon, Hyun Ju
AU - Lerman, Amir
PY - 2007/10
Y1 - 2007/10
N2 - Background and Objectives: Nitroglycerin-mediated arterial dilation (NMD) was shown to be preserved in most previous studies, and this is possibly due to using a single high dose of nitroglycerin (NTG), which causes maximal arterial dilation. We sought to evaluate the clinical factors of flow-mediated dilation (FMD) and NMD at different doses of NTG in the patients with coronary artery disease (CAD). Subjects and Methods: Thirty-two consecutive patients (mean age: 61 years old, 18 males) with angiographically proven CAD underwent FMD and NMD at total cumulative doses of 25 μg, 175 μg and 325 μg with using high-resolution ultrasound for the imaging. Results: The FMD, NMD (25 μg), NMD (175 μg) and NMD (325 μg) were 4.72 ± 1.82%, 7.08 ± 3.02%, 13.33 ± 6.14% and 15.89 ± 7.24%, respectively (p<0.001 compared with each other). Univariate analysis showed that the FMD is associated with the serum homocysteine level, the NMD (25 μg) is associated with the body mass index, the NMD (175 μg) is associated with the fasting blood sugar and the ejection fraction, and the NMD (325 μg) is associated with the fasting blood sugar, while there was no significant difference of the FMD and NMD according to the presence of CAD risk factors. Multivariate analysis disclosed that the independent factors of FMD were the serum homocysteine and triglyceride levels, and those of NMD (25 μg) were hypertension, a low ejection fraction and severe coronary angiographic findings, while there was no independent factor for NMD (175 μg) and NMD (325 μg). Conclusion: This study suggests that hypertension, a low ejection fraction and significant stenotic coronary lesion may be associated with endothelium-independent smooth muscle dysfunction at low dose NTG, while the serum homocysteine and triglyceride levels are associated with endothelium-dependent endothelial dysfunction in the patients with CAD. Using low-dose NTG is important when measuring the NMD.
AB - Background and Objectives: Nitroglycerin-mediated arterial dilation (NMD) was shown to be preserved in most previous studies, and this is possibly due to using a single high dose of nitroglycerin (NTG), which causes maximal arterial dilation. We sought to evaluate the clinical factors of flow-mediated dilation (FMD) and NMD at different doses of NTG in the patients with coronary artery disease (CAD). Subjects and Methods: Thirty-two consecutive patients (mean age: 61 years old, 18 males) with angiographically proven CAD underwent FMD and NMD at total cumulative doses of 25 μg, 175 μg and 325 μg with using high-resolution ultrasound for the imaging. Results: The FMD, NMD (25 μg), NMD (175 μg) and NMD (325 μg) were 4.72 ± 1.82%, 7.08 ± 3.02%, 13.33 ± 6.14% and 15.89 ± 7.24%, respectively (p<0.001 compared with each other). Univariate analysis showed that the FMD is associated with the serum homocysteine level, the NMD (25 μg) is associated with the body mass index, the NMD (175 μg) is associated with the fasting blood sugar and the ejection fraction, and the NMD (325 μg) is associated with the fasting blood sugar, while there was no significant difference of the FMD and NMD according to the presence of CAD risk factors. Multivariate analysis disclosed that the independent factors of FMD were the serum homocysteine and triglyceride levels, and those of NMD (25 μg) were hypertension, a low ejection fraction and severe coronary angiographic findings, while there was no independent factor for NMD (175 μg) and NMD (325 μg). Conclusion: This study suggests that hypertension, a low ejection fraction and significant stenotic coronary lesion may be associated with endothelium-independent smooth muscle dysfunction at low dose NTG, while the serum homocysteine and triglyceride levels are associated with endothelium-dependent endothelial dysfunction in the patients with CAD. Using low-dose NTG is important when measuring the NMD.
KW - Coronary atherosclerosis
KW - Endothelium
KW - Muscle, smooth
KW - Nitroglycerin
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U2 - 10.4070/kcj.2007.37.10.470
DO - 10.4070/kcj.2007.37.10.470
M3 - Article
AN - SCOPUS:36749003354
SN - 1738-5520
VL - 37
SP - 470
EP - 474
JO - Korean Circulation Journal
JF - Korean Circulation Journal
IS - 10
ER -