Hypersexuality with antiparkinsonian therapy

R. J. Uitti, C. M. Tanner, A. H. Rajput, C. G. Goetz, H. L. Klawans, B. Thiessen

Research output: Contribution to journalArticlepeer-review

191 Scopus citations


Thirteen parkinsonian patients drawn from two large parkinsonism clinics experienced hypersexuality as a consequence of anti-parkinsonian therapy. The cases include only those whose sexual behavior on treatment became a concern to the patient's family or a social agency. The majority of patients were men and had a relatively early onset of parkinsonian symptomatology. There was no relation between functional improvement and incereased sexuality. Most patients showed some element of dose dependency between antiparkinsonian drugs and the hypersexual behavior. Prior sexual profile included from no sexual outlet to hypersexuality. Neither the prior history of psychiatric illness nor brain damage predisposed to such response on treatment, and in most patients, it was not a part of hypomania or a more diffuse psychiatric disturbance. We propose that hypersexuality on antiparkinsonian drugs is consequent to inhibition of prolactin secretion.

Original languageEnglish (US)
Pages (from-to)375-383
Number of pages9
JournalClinical Neuropharmacology
Issue number5
StatePublished - 1989


  • Parkinsonism
  • dopamine agonists
  • drug therapy
  • hypersexuality
  • levodopa
  • thalamotomy

ASJC Scopus subject areas

  • Pharmacology
  • Clinical Neurology
  • Pharmacology (medical)


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