Hyperglycemia and hemorrhagic transformation of cerebral infarcts

Joseph P. Broderick, Timothy Hagen, Thomas Brott, Thomas Tomsick

Research output: Contribution to journalArticlepeer-review

77 Scopus citations


BackgroundIdentification of factors that predispose to bleeding into ischemic brain could lead to safer use of thrombolytic agents in the setting of ischemic stroke. Recently de Courten-Meyers and colleagues reported that occluding the middle cerebral artery of markedly hyperglycemic cats was associated with 5-fold more frequent and 25-fold more extensive hemorrhage into infarcts than in normoglycemic animals. Hemorrhage associated with hyperglycemia in cats was much more pronounced with reperfusion than with permanent middle cerebral artery occlusion.

Original languageEnglish (US)
Pages (from-to)484-487
Number of pages4
Issue number3
StatePublished - Mar 1995

ASJC Scopus subject areas

  • Clinical Neurology
  • Cardiology and Cardiovascular Medicine
  • Advanced and Specialized Nursing


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