Hyperbaric oxygen as a treatment modality in cyclophosphamide-induced hemorrhagic cystitis

Dominder Kaur; Shakila P. Khan; Vilmarie Rodriguez; Carola Arndt; Paul Claus

doi:10.1111/petr.13171

Hyperbaric oxygen as a treatment modality in cyclophosphamide-induced hemorrhagic cystitis

Dominder Kaur, Shakila P. Khan, Vilmarie Rodriguez, Carola Arndt, Paul Claus

Pediatric and Adolescent Medicine

Research output: Contribution to journal › Article › peer-review

2 Scopus citations

Abstract

Late-onset HC is a well-recognized complication associated with cyclophosphamide/acrolein-induced toxicity. It poses a management challenge when hyperhydration and bladder irrigation do not result in clinical improvement as desired. The data regarding use of hyperbaric oxygen therapy (HBO2) as an early treatment modality in this clinical setting are limited. We present 2 cases, that were refractory to hyperhydration and bladder irrigation but responded to HBO2. They were treated with 20-30 daily sessions over weekdays with 100% oxygen for 90 minutes at 2 atmospheric pressure units (2 atm). Both patients reported improved symptoms within the first 15 sessions, and hematuria diminished by 20 sessions. Hyperbaric oxygen is a less invasive, outpatient therapy that is effective for treatment of HC and is tolerated well by young patients.

Original language	English (US)
Article number	e13171
Journal	Pediatric Transplantation
Volume	22
Issue number	4
DOIs	https://doi.org/10.1111/petr.13171
State	Published - Jun 2018

Keywords

HC
HSCT
bone marrow transplant
cyclophosphamide
hyperbaric oxygen
pediatric

ASJC Scopus subject areas

Pediatrics, Perinatology, and Child Health
Transplantation

Access to Document

10.1111/petr.13171

Cite this

@article{135ac933491746c5a34e1c6798087c59,

title = "Hyperbaric oxygen as a treatment modality in cyclophosphamide-induced hemorrhagic cystitis",

abstract = "Late-onset HC is a well-recognized complication associated with cyclophosphamide/acrolein-induced toxicity. It poses a management challenge when hyperhydration and bladder irrigation do not result in clinical improvement as desired. The data regarding use of hyperbaric oxygen therapy (HBO2) as an early treatment modality in this clinical setting are limited. We present 2 cases, that were refractory to hyperhydration and bladder irrigation but responded to HBO2. They were treated with 20-30 daily sessions over weekdays with 100% oxygen for 90 minutes at 2 atmospheric pressure units (2 atm). Both patients reported improved symptoms within the first 15 sessions, and hematuria diminished by 20 sessions. Hyperbaric oxygen is a less invasive, outpatient therapy that is effective for treatment of HC and is tolerated well by young patients.",

keywords = "HC, HSCT, bone marrow transplant, cyclophosphamide, hyperbaric oxygen, pediatric",

author = "Dominder Kaur and Khan, {Shakila P.} and Vilmarie Rodriguez and Carola Arndt and Paul Claus",

note = "Publisher Copyright: {\textcopyright} 2018 John Wiley & Sons A/S. Published by John Wiley & Sons Ltd",

year = "2018",

month = jun,

doi = "10.1111/petr.13171",

language = "English (US)",

volume = "22",

journal = "Pediatric Transplantation",

issn = "1397-3142",

publisher = "Wiley-Blackwell",

number = "4",

}

TY - JOUR

T1 - Hyperbaric oxygen as a treatment modality in cyclophosphamide-induced hemorrhagic cystitis

AU - Kaur, Dominder

AU - Khan, Shakila P.

AU - Rodriguez, Vilmarie

AU - Arndt, Carola

AU - Claus, Paul

PY - 2018/6

Y1 - 2018/6

N2 - Late-onset HC is a well-recognized complication associated with cyclophosphamide/acrolein-induced toxicity. It poses a management challenge when hyperhydration and bladder irrigation do not result in clinical improvement as desired. The data regarding use of hyperbaric oxygen therapy (HBO2) as an early treatment modality in this clinical setting are limited. We present 2 cases, that were refractory to hyperhydration and bladder irrigation but responded to HBO2. They were treated with 20-30 daily sessions over weekdays with 100% oxygen for 90 minutes at 2 atmospheric pressure units (2 atm). Both patients reported improved symptoms within the first 15 sessions, and hematuria diminished by 20 sessions. Hyperbaric oxygen is a less invasive, outpatient therapy that is effective for treatment of HC and is tolerated well by young patients.

AB - Late-onset HC is a well-recognized complication associated with cyclophosphamide/acrolein-induced toxicity. It poses a management challenge when hyperhydration and bladder irrigation do not result in clinical improvement as desired. The data regarding use of hyperbaric oxygen therapy (HBO2) as an early treatment modality in this clinical setting are limited. We present 2 cases, that were refractory to hyperhydration and bladder irrigation but responded to HBO2. They were treated with 20-30 daily sessions over weekdays with 100% oxygen for 90 minutes at 2 atmospheric pressure units (2 atm). Both patients reported improved symptoms within the first 15 sessions, and hematuria diminished by 20 sessions. Hyperbaric oxygen is a less invasive, outpatient therapy that is effective for treatment of HC and is tolerated well by young patients.

KW - HC

KW - HSCT

KW - bone marrow transplant

KW - cyclophosphamide

KW - hyperbaric oxygen

KW - pediatric

UR - http://www.scopus.com/inward/record.url?scp=85044339045&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=85044339045&partnerID=8YFLogxK

U2 - 10.1111/petr.13171

DO - 10.1111/petr.13171

M3 - Article

C2 - 29569791

AN - SCOPUS:85044339045

SN - 1397-3142

VL - 22

JO - Pediatric Transplantation

JF - Pediatric Transplantation

IS - 4

M1 - e13171

ER -

Hyperbaric oxygen as a treatment modality in cyclophosphamide-induced hemorrhagic cystitis

Abstract

Keywords

ASJC Scopus subject areas

Access to Document

Other files and links

Fingerprint

Cite this