Abstract
Background: Hydroxyurea is an antineoplastic agent commonly used to treat myeloproliferative disorders and other nonneoplastic conditions. Objective: To further define the typical features of hydroxyurea-related cutaneous ulcers of the leg. Design: Retrospective, descriptive study of the medical records of patients who developed leg ulcers while receiving hydroxyurea therapy. Setting: A tertiary care medical center. Patients: Patients with myeloproliferative disorders who were treated with hydroxyurea. Results: 14 patients with extremely painful leg ulcers were identified. The most common ulcer site was the malleoli. Multiple ulcers were seen in 64% of patients. Patients had received hydroxyurea for an average of 6 years before ulcers developed. All ulcers healed after discontinuation of hydroxyurea treatment, and 2 patients developed ulcers after treatment was restarted. Conclusion: Hydroxyurea induces painful leg ulcers that are usually difficult to treat and require cessation of hydroxyurea therapy.
Original language | English (US) |
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Pages (from-to) | 29-32 |
Number of pages | 4 |
Journal | Annals of internal medicine |
Volume | 128 |
Issue number | 1 |
DOIs | |
State | Published - Jan 1 1998 |
ASJC Scopus subject areas
- Internal Medicine