Huntingtin's critical cleavage

John D. Fryer; Huda Y. Zoghbi

doi:10.1038/nn0906-1088

Huntingtin's critical cleavage

John D. Fryer, Huda Y. Zoghbi

Neuroscience

Research output: Contribution to journal › Short survey › peer-review

8 Scopus citations

Abstract

The early pathogenic events leading to neurodegeneration in Huntington disease are not clear. A recent paper shows that mutating a caspase-6 cleavage site in the huntingtin protein is sufficient to prevent pathogenesis.

Original language	English (US)
Pages (from-to)	1088-1089
Number of pages	2
Journal	Nature Neuroscience
Volume	9
Issue number	9
DOIs	https://doi.org/10.1038/nn0906-1088
State	Published - Sep 2006

ASJC Scopus subject areas

Neuroscience(all)

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10.1038/nn0906-1088

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title = "Huntingtin's critical cleavage",

abstract = "The early pathogenic events leading to neurodegeneration in Huntington disease are not clear. A recent paper shows that mutating a caspase-6 cleavage site in the huntingtin protein is sufficient to prevent pathogenesis.",

author = "Fryer, {John D.} and Zoghbi, {Huda Y.}",

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Huntingtin's critical cleavage

Abstract

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