Human studies in the pathophysiology of migraine: Genetics and functional neuroimaging

F. Michael Cutrer, Jonathan H. Smith

Research output: Contribution to journalReview articlepeer-review

20 Scopus citations


The expansion of technologies available for the study of migraine pathophysiology has evolved greatly over the last 15 years. Two areas of rapid progress are investigations focusing on the genetics of migraine and others utilizing novel functional neuroimaging techniques. Genetic studies are increasingly focusing on sporadic migraine and the utilization of unbiased searches of the human genome to identify novel variants associated with disease susceptibility. At the same time, neuroimaging studies have provided novel insights into the altered neuronal and network dynamics of the migrainous brain. These 2 parallel approaches provide complementary insights into the complexity and heterogeneity of migraine.

Original languageEnglish (US)
Pages (from-to)401-412
Number of pages12
Issue number2
StatePublished - Feb 2013


  • genetics in migraine
  • migraine pathophysiology
  • neuroimaging

ASJC Scopus subject areas

  • Neurology
  • Clinical Neurology


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