Human protein reference database--2006 update.

Gopa R. Mishra, M. Suresh, K. Kumaran, N. Kannabiran, Shubha Suresh, P. Bala, K. Shivakumar, N. Anuradha, Raghunath Reddy, T. Madhan Raghavan, Shalini Menon, G. Hanumanthu, Malvika Gupta, Sapna Upendran, Shweta Gupta, M. Mahesh, Bincy Jacob, Pinky Mathew, Pritam Chatterjee, K. S. ArunSalil Sharma, K. N. Chandrika, Nandan Deshpande, Kshitish Palvankar, R. Raghavnath, R. Krishnakanth, Hiren Karathia, B. Rekha, Rashmi Nayak, G. Vishnupriya, H. G.Mohan Kumar, M. Nagini, G. S.Sameer Kumar, Rojan Jose, P. Deepthi, S. Sujatha Mohan, T. K. Gandhi, H. C. Harsha, Krishna S. Deshpande, Malabika Sarker, T. S.Keshava Prasad, Akhilesh Pandey

Research output: Contribution to journalArticlepeer-review

463 Scopus citations


Human Protein Reference Database (HPRD) ( was developed to serve as a comprehensive collection of protein features, post-translational modifications (PTMs) and protein-protein interactions. Since the original report, this database has increased to >20 000 proteins entries and has become the largest database for literature-derived protein-protein interactions (>30 000) and PTMs (>8000) for human proteins. We have also introduced several new features in HPRD including: (i) protein isoforms, (ii) enhanced search options, (iii) linking of pathway annotations and (iv) integration of a novel browser, GenProt Viewer (, developed by us that allows integration of genomic and proteomic information. With the continued support and active participation by the biomedical community, we expect HPRD to become a unique source of curated information for the human proteome and spur biomedical discoveries based on integration of genomic, transcriptomic and proteomic data.

Original languageEnglish (US)
Pages (from-to)D411-414
JournalNucleic acids research
Issue numberDatabase issue
StatePublished - Jan 1 2006

ASJC Scopus subject areas

  • Genetics


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