Human leukocyte antigen polymorphisms: Variable humoral immune responses to viral vaccines

Inna G. Ovsyannikova, Neelam Dhiman, Robert M. Jacobson, Gregory A. Poland

Research output: Contribution to journalReview articlepeer-review

29 Scopus citations


Antibody formation in response to antigen stimulation remains the basis for measuring an individual's response and protection for most viral vaccines. A significant proportion of the variation in individual humoral immune response to vaccination appears to be genetic. The collection of genes found on chromosome 6 forming the human leukocyte antigen system provides one of the greatest sources of genetic variation in Individuals with respect to their immunological responses. Recent research has demonstrated significant associations between vaccine response and human leukocyte antigen alleles. These associations not only explain why vaccine-induced humoral immune responses vary among individuals and between populations, but these variations may also hold the key to the development of future generations of vaccines.

Original languageEnglish (US)
Pages (from-to)33-43
Number of pages11
JournalExpert review of vaccines
Issue number1
StatePublished - Feb 2006


  • Antibody formation
  • Antigen processing
  • Antigens
  • Cytokines
  • Human leukocyte antigens
  • Humoral immunity
  • Measles
  • T cells
  • Viral vaccines

ASJC Scopus subject areas

  • Immunology
  • Molecular Medicine
  • Pharmacology
  • Drug Discovery


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