Human growth hormone response to repeated bouts of aerobic exercise

J. A. Kanaley, J. Y. Weltman, J. D. Veldhuis, A. D. Rogol, M. L. Hartman, A. Weltman

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106 Scopus citations


We examined whether repeated bouts of exercise could override growth hormone (GH) auto-negative feedback. Seven moderately trained men were studied on three occasions: a control day (C), a sequential exercise day (SEB; at 1000, 1130, and 1300), and a delayed exercise day (DEB; at 1000, 1400, and 1800). The duration of each exercise bout was 30 min at 70% maximal O2 consumption (V̇O(2max)) on a cycle ergometer. Standard meals were provided at 0600 and 2200. GH was measured every 5-10 min for 24 h (0800- 0800). Daytime (0800-2200) integrated OH concentrations were ~150-160% greater during SEB and DEB than during C: 1,282 ± 345, 3,192 ± 669, and 3,389 ± 991 min · μg · l-1 for C, SEB, and DEB, respectively [SEB > C (P <0.06), DEB > C (P < 0.03)]. There were no differences in GH release during sleep (2300-0700). Deconvolution analysis revealed that the increase in 14-h integrated GH concentration on DEB was accounted for by an increase in the mass of GH secreted per pulse (per liter of distribution volume, l(v)):7.0 ± 2.9 and 15.9 ± 2.6 μg/l(v) for C and DEB, respectively (P < 0.01). Comparison of 1.5-h integrated GH concentrations on the SEB and DEB days (30 min exercise + 60 min recovery) revealed that, with each subsequent exercise bout, GH release apparently increased progressively, with a slightly greater increase on the DEB day [SEB vs. DEB: 497 ± 162 vs. 407 ± 166 (bout 1), 566 ± 152 vs. 854 ± 184 (bout 2), and 633 ± 149 vs. 1,030 ± 352 min · μg · l-1 (bout 3), P < 0.05]. We conclude that the GH response to acute aerobic exercise is augmented with repeated bouts of exercise.

Original languageEnglish (US)
Pages (from-to)1756-1761
Number of pages6
JournalJournal of applied physiology
Issue number5
StatePublished - Nov 1997


  • Deconvolution
  • Endocrinology

ASJC Scopus subject areas

  • Physiology
  • Physiology (medical)


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