Human-derived natural antibodies: Biomarkers and potential therapeutics

Xiaohua Xu, Sher May Ng, Eamonn Hassouna, Arthur Warrington, Sang Hyun Oh, Moses Rodriguez

Research output: Contribution to journalReview articlepeer-review

10 Scopus citations


The immune system generates antibodies and antigen-specific T-cells as basic elements of the immune networks that differentiate self from non-self in a finely tuned manner. The antigen-specific nature of immune responses ensures that normal immune activation contains non-self when tolerating self. Here we review the B-1 subset of lymphocytes which produce self-reactive antibodies. By analyzing the IgM class of natural antibodies that recognize antigens from the nervous system, we emphasize that natural antibodies are biomarkers of how the immune system monitors the host. The immune response activated against self can be detrimental when triggered in an autoimmune genetic background. In contrast, tuning immune activity with natural antibodies is a potential therapeutic strategy.

Original languageEnglish (US)
Pages (from-to)25-39
Number of pages15
JournalFuture Neurology
Issue number1
StatePublished - Jan 1 2015


  • B-1 cell
  • CNS inflammation
  • T-cell activation
  • autoimmunity
  • natural auto-antibody

ASJC Scopus subject areas

  • Neurology
  • Clinical Neurology


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