HTR2A: Association and expression studies in neuropsychiatric genetics

Nadine Norton, Michael J. Owen

Research output: Contribution to journalReview articlepeer-review

78 Scopus citations


Over the last decade the gene encoding 5-hydroxytryptamine (serotonin) receptor 2A (HTR2A) has been implicated as a functional candidate in many neuropsychiatric phenotypes including: schizophrenia, attention deficit hyperactivity disorder (ADHD), affective disorders, eating disorders, anxiety disorders, obsessive-compulsive disorder, suicide and Alzheimer's disease (AD). Different studies have tested for genetic association (case-control and family-based studies), protein expression (receptor binding assays), transcriptional expression (mRNA assays) and allelic expression. In this review we examine and summarize these findings in various neuropsychiatric phenotypes.

Original languageEnglish (US)
Pages (from-to)121-129
Number of pages9
JournalAnnals of Medicine
Issue number2
StatePublished - 2005


  • 5-hydroxytryptamine (serotonin) receptor 2A
  • 5HT2A
  • Association
  • HTR2A
  • Neuropsychiatric
  • Serotonin 5-HT-2 receptor

ASJC Scopus subject areas

  • Medicine(all)


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