HSP70-1 promoter region alleles and susceptibility to rheumatoid arthritis

S. A. Quadri; V. Taneja; N. K. Mehra; D. P. Singal

HSP70-1 promoter region alleles and susceptibility to rheumatoid arthritis

S. A. Quadri, V. Taneja, N. K. Mehra, D. P. Singal

Immunology

Research output: Contribution to journal › Article › peer-review

11 Scopus citations

Abstract

The distribution of HSP70-1 promoter alleles was studied in 90 adult Caucasian RA patients (65 European and 25 Asian Indian) and 113 normal controls (60 European and 53 Asian Indian). The HSP70-1 promoter alleles were defined by oligonucleotide typing of polymerase chain (PCR)-amplified genomic DNA. The prevalence of HSP70-1 promoter allele "B" was significantly (p<0.0004, pc<0.0012; RR=5.1) higher in RA patients (22.2%) compared to normal controls (5.3%). It is likely therefore that HSP70-1 promoter allele B is associated with susceptibility to RA.

Original language	English (US)
Pages (from-to)	183-185
Number of pages	3
Journal	Clinical and experimental rheumatology
Volume	14
Issue number	2
State	Published - Mar 1 1996

Keywords

Extended haplotypes
HLA
HSP70-1 promoter
Rheumatoid arthritis

ASJC Scopus subject areas

Rheumatology
Immunology and Allergy
Immunology

Cite this

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title = "HSP70-1 promoter region alleles and susceptibility to rheumatoid arthritis",

abstract = "The distribution of HSP70-1 promoter alleles was studied in 90 adult Caucasian RA patients (65 European and 25 Asian Indian) and 113 normal controls (60 European and 53 Asian Indian). The HSP70-1 promoter alleles were defined by oligonucleotide typing of polymerase chain (PCR)-amplified genomic DNA. The prevalence of HSP70-1 promoter allele {"}B{"} was significantly (p<0.0004, pc<0.0012; RR=5.1) higher in RA patients (22.2%) compared to normal controls (5.3%). It is likely therefore that HSP70-1 promoter allele B is associated with susceptibility to RA.",

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AU - Quadri, S. A.

AU - Taneja, V.

AU - Mehra, N. K.

AU - Singal, D. P.

PY - 1996/3/1

Y1 - 1996/3/1

N2 - The distribution of HSP70-1 promoter alleles was studied in 90 adult Caucasian RA patients (65 European and 25 Asian Indian) and 113 normal controls (60 European and 53 Asian Indian). The HSP70-1 promoter alleles were defined by oligonucleotide typing of polymerase chain (PCR)-amplified genomic DNA. The prevalence of HSP70-1 promoter allele "B" was significantly (p<0.0004, pc<0.0012; RR=5.1) higher in RA patients (22.2%) compared to normal controls (5.3%). It is likely therefore that HSP70-1 promoter allele B is associated with susceptibility to RA.

AB - The distribution of HSP70-1 promoter alleles was studied in 90 adult Caucasian RA patients (65 European and 25 Asian Indian) and 113 normal controls (60 European and 53 Asian Indian). The HSP70-1 promoter alleles were defined by oligonucleotide typing of polymerase chain (PCR)-amplified genomic DNA. The prevalence of HSP70-1 promoter allele "B" was significantly (p<0.0004, pc<0.0012; RR=5.1) higher in RA patients (22.2%) compared to normal controls (5.3%). It is likely therefore that HSP70-1 promoter allele B is associated with susceptibility to RA.

KW - Extended haplotypes

KW - HLA

KW - HSP70-1 promoter

KW - Rheumatoid arthritis

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HSP70-1 promoter region alleles and susceptibility to rheumatoid arthritis

Abstract

Keywords

ASJC Scopus subject areas

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