TY - JOUR
T1 - How to record high-frequency oscillations in epilepsy
T2 - A practical guideline
AU - Zijlmans, Maeike
AU - Worrell, Gregory A.
AU - Dümpelmann, Matthias
AU - Stieglitz, Thomas
AU - Barborica, Andrei
AU - Heers, Marcel
AU - Ikeda, Akio
AU - Usui, Naotaka
AU - Le Van Quyen, Michel
N1 - Funding Information:
The 2nd international workshop on High Frequency Oscillations in Epilepsy held in Freiburg, Germany, was supported by the grant German Research Foundation JA1725/3-1. MZ was supported by the Netherlands Organization for Scientific Research grant 91615149. MH was funded by the Faculty of Medicine, Bochum University: FoRUM research grant K062-11. The work of MD, MH, and TS has been partly funded within the cluster of excellence BrainLinks-BrainTools by the German Research Foundation (EXC 1086). AB was supported by Romanian government “Executive Unit for Financing Higher Education, Research, Development and Innovation” (UEFISCDI) research grant PN-II-ID-PCE-2011-3-0240. AI was supported by Japanese grants MEXT KAKENHI15H05874 and JSPS2629320. MLVQ was supported by funding from the program “Investissements d'avenir” ANR-10-IAIHU-06 and fromthe brain and spine institute (ICM).
Publisher Copyright:
Wiley Periodicals, Inc. © 2017 International League Against Epilepsy
PY - 2017/8
Y1 - 2017/8
N2 - Objective: Technology for localizing epileptogenic brain regions plays a central role in surgical planning. Recent improvements in acquisition and electrode technology have revealed that high-frequency oscillations (HFOs) within the 80–500 Hz frequency range provide the neurophysiologist with new information about the extent of the epileptogenic tissue in addition to ictal and interictal lower frequency events. Nevertheless, two decades after their discovery there remain questions about HFOs as biomarkers of epileptogenic brain and there use in clinical practice. Methods: In this review, we provide practical, technical guidance for epileptologists and clinical researchers on recording, evaluation, and interpretation of ripples, fast ripples, and very high-frequency oscillations. Results: We emphasize the importance of low noise recording to minimize artifacts. HFO analysis, either visual or with automatic detection methods, of high fidelity recordings can still be challenging because of various artifacts including muscle, movement, and filtering. Magnetoencephalography and intracranial electroencephalography (iEEG) recordings are subject to the same artifacts. Significance: High-frequency oscillations are promising new biomarkers in epilepsy. This review provides interested researchers and clinicians with a review of current state of the art of recording and identification and potential challenges to clinical translation.
AB - Objective: Technology for localizing epileptogenic brain regions plays a central role in surgical planning. Recent improvements in acquisition and electrode technology have revealed that high-frequency oscillations (HFOs) within the 80–500 Hz frequency range provide the neurophysiologist with new information about the extent of the epileptogenic tissue in addition to ictal and interictal lower frequency events. Nevertheless, two decades after their discovery there remain questions about HFOs as biomarkers of epileptogenic brain and there use in clinical practice. Methods: In this review, we provide practical, technical guidance for epileptologists and clinical researchers on recording, evaluation, and interpretation of ripples, fast ripples, and very high-frequency oscillations. Results: We emphasize the importance of low noise recording to minimize artifacts. HFO analysis, either visual or with automatic detection methods, of high fidelity recordings can still be challenging because of various artifacts including muscle, movement, and filtering. Magnetoencephalography and intracranial electroencephalography (iEEG) recordings are subject to the same artifacts. Significance: High-frequency oscillations are promising new biomarkers in epilepsy. This review provides interested researchers and clinicians with a review of current state of the art of recording and identification and potential challenges to clinical translation.
KW - EEG
KW - High-frequency oscillations (HFOs)
KW - Magnetoencephalography
KW - Ripples
KW - pHFOs
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U2 - 10.1111/epi.13814
DO - 10.1111/epi.13814
M3 - Review article
C2 - 28622421
AN - SCOPUS:85021297750
SN - 0013-9580
VL - 58
SP - 1305
EP - 1315
JO - Epilepsia
JF - Epilepsia
IS - 8
ER -