TY - JOUR
T1 - How relevant is hormone receptor status in the context of outcome to HER2-positive breast cancer?
AU - Norton, Nadine
AU - Perez, Edith A.
PY - 2013/1/14
Y1 - 2013/1/14
N2 - Clinical outcome of patients with breast cancer is based on patient and tumor-related factors. The relevant tumor-related factors include anatomical extent and biology. Of the prognostic and predictive biological markers available, hormone receptors (defined as estrogen and progesterone receptors) and HER2 receptors, have been independently validated. Pertinent questions to be addressed include their combined impact on prognosis, their relevance in terms of sites of metastases, and whether they change in primary versus recurrent tumors. Although these questions are being addressed in clinical trials, epidemiological results, such as those derived from the National Comprehensive Cancer Network dataset, add perspective to our understanding of these two most relevant biological prognostic/predictive markers.
AB - Clinical outcome of patients with breast cancer is based on patient and tumor-related factors. The relevant tumor-related factors include anatomical extent and biology. Of the prognostic and predictive biological markers available, hormone receptors (defined as estrogen and progesterone receptors) and HER2 receptors, have been independently validated. Pertinent questions to be addressed include their combined impact on prognosis, their relevance in terms of sites of metastases, and whether they change in primary versus recurrent tumors. Although these questions are being addressed in clinical trials, epidemiological results, such as those derived from the National Comprehensive Cancer Network dataset, add perspective to our understanding of these two most relevant biological prognostic/predictive markers.
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U2 - 10.1186/bcr3335
DO - 10.1186/bcr3335
M3 - Editorial
C2 - 23316883
AN - SCOPUS:84872382810
SN - 1465-5411
VL - 15
JO - Breast Cancer Research
JF - Breast Cancer Research
IS - 1
M1 - 101
ER -