@article{2115fe18686f49ee991114e934b36db0,
title = "Homer1a drives homeostatic scaling-down of excitatory synapses during sleep",
abstract = "Sleep is an essential process that supports learning and memory by acting on synapses through poorly understood molecular mechanisms. Using biochemistry, proteomics, and imaging in mice, we find that during sleep, synapses undergo widespread alterations in composition and signaling, including weakening of synapses through removal and dephosphorylation of synaptic AMPA-type glutamate receptors. These changes are driven by the immediate early gene Homer1a and signaling from group I metabotropic glutamate receptors mGluR1/5. Homer1a serves as a molecular integrator of arousal and sleep need via the wake- and sleep-promoting neuromodulators, noradrenaline and adenosine, respectively. Our data suggest that homeostatic scaling-down, a global form of synaptic plasticity, is active during sleep to remodel synapses and participates in the consolidation of contextual memory.",
author = "Diering, {Graham H.} and Nirujogi, {Raja S.} and Roth, {Richard H.} and Worley, {Paul F.} and Akhilesh Pandey and Huganir, {Richard L.}",
note = "Funding Information: All proteomics data obtained in this study are available in the PRIDE repository with the data set identifier PXD004537. The authors thank members of the Huganir laboratory, especially I. Hong, S. Heo, and N. Hussain, for insightful comments and critical reading of the manuscript. Image analysis software was developed by R. Cudmore and D. Linden, Department of Neuroscience, Johns Hopkins University. G.H.D. is a recipient of a fellowship award from the Canadian Institutes for Health Research. Funding was provided by an NIH grant (P50MH100024, RO1NS036715, to R.L.H.), an NIH shared instrumentation grant (S10OD021844, to A.P.), and the Center for Proteomics Discovery at Johns Hopkins University. Data are stored and curated on a secure server located in the Department of Neuroscience at Johns Hopkins University. Data will be made available upon request. Publisher Copyright: {\textcopyright} 2017, American Association for the Advancement of Science. All rights reserved.",
year = "2017",
month = feb,
day = "3",
doi = "10.1126/science.aai8355",
language = "English (US)",
volume = "355",
pages = "511--515",
journal = "Science",
issn = "0036-8075",
publisher = "American Association for the Advancement of Science",
number = "6324",
}