Histopathology of Meningiomas

Research output: Chapter in Book/Report/Conference proceedingChapter

Abstract

Meningiomas are considered to arise from meningothelial cells, whose cytomorphology they recapitulate. In this chapter, we review the characteristic histological features of meningioma, including classic architectural and cytological features. There exists a broad spectrum of morphological variants of meningioma. The 2021 WHO Classification recognizes nine benign (grade 1), three intermediate-grade (grade 2), and three malignant (grade 3) variants. We review the characteristic histological features of these meningioma variants, describe immunohistochemical stains, which may assist with establishing a diagnosis, and discuss differential diagnostic considerations that may prove challenging for a diagnosis of meningioma.

Original languageEnglish (US)
Title of host publicationAdvances in Experimental Medicine and Biology
PublisherSpringer
Pages35-45
Number of pages11
DOIs
StatePublished - 2023

Publication series

NameAdvances in Experimental Medicine and Biology
Volume1416
ISSN (Print)0065-2598
ISSN (Electronic)2214-8019

Keywords

  • Anaplastic
  • Atypical
  • Benign
  • Classification
  • Diagnosis
  • Immunohistochemistry
  • WHO grade

ASJC Scopus subject areas

  • General Biochemistry, Genetics and Molecular Biology

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