Histopathology of autoimmune bullous dermatoses: what's new?

Burak Tekin, Emma F. Johnson, Carilyn N. Wieland, Lawrence E. Gibson, Michael J. Camilleri, Amer N. Kalaaji, Nneka I. Comfere, Margot S. Peters, Julia S. Lehman

Research output: Contribution to journalReview articlepeer-review


Autoimmune bullous dermatoses are characterized by the presence of tissue-bound and often circulating pathogenic autoantibodies targeting structural components of the skin and/or mucous membranes. The diagnostic workup for this heterogeneous group of disorders consists of a multi-step process, of which the light microscopic examination is a crucial component. This review is organized following a classification scheme that is based on two main histopathologic features, namely level of intraepithelial split and composition of the inflammatory infiltrate. Overall, we aim to place emphasis on the histopathologic clues that can assist pathologists in differential diagnosis and review the updates in the literature.

Original languageEnglish (US)
Pages (from-to)69-89
Number of pages21
JournalHuman Pathology
StatePublished - Oct 2022


  • Acantholysis
  • Autoimmune bullous
  • Dermatitis herpetiformis
  • Direct immunofluorescence
  • Immunobullous
  • Linear IgA bullous dermatosis
  • Pemphigoid
  • Pemphigus

ASJC Scopus subject areas

  • Pathology and Forensic Medicine


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