Histopathological changes in the gastrointestinal tract due to drugs: An update for the surgical pathologist (part I of II)

Giovanni De Petris, Sonia Gatius Caldero, Longwen Chen, Shu Yuan Xiao, Bal M. Dhungel, Amy J. Wendel Spizcka, Dora Lam-Himlin

Research output: Contribution to journalReview articlepeer-review

14 Scopus citations


Abnormalities of the gastrointestinal (GI) tract due to drugs (AGIDs) are numerous and have significant impact. The aim of this narrative review is to help the practicing surgical pathologist recognize selected AGIDs. The adverse drug effects presented were chosen with an emphasis on recent and significant pathological and clinical contributions. The selection was based on a thorough review of the PUBMED-based literature and on the authors' opinions and experience. In the first part of the review, diagnostic abnormalities due to crystals (eg, iron, biphosphonates, nonsystemic drugs), mitosis arresting drugs (colchicine, taxanes), and biological agents, especially ipilimumab, are discussed. Some AGIDs' histopathologic features can be easily recognized. It is however the clinical correlation that in many cases of AGIDs will provide the necessary support for a drug effect diagnosis. The identification of AGIDs requires heightened awareness of the medical team in which close collaboration of pathologists and clinicians cannot be overemphasized.

Original languageEnglish (US)
Pages (from-to)120-128
Number of pages9
JournalInternational Journal of Surgical Pathology
Issue number2
StatePublished - Apr 2014


  • adverse gastrointestinal tract drug effect
  • crystals in the gastrointestinal tract
  • ipilimumab
  • nonsteroidal anti-inflammatory drugs
  • olmesartan

ASJC Scopus subject areas

  • Surgery
  • Anatomy
  • Pathology and Forensic Medicine


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