Histopathologic features of noninfectious granulomatous disorders involving the skin

Julia S. Lehman, Olayemi Sokumbi, Margot S. Peters, Alina G. Bridges, Nneka I. Comfere, Lawrence E. Gibson, Carilyn N. Wieland

Research output: Contribution to journalReview articlepeer-review


Granulomatous dermatoses may represent primary skin inflammation or can serve as the harbinger of a multitude of underlying systemic disorders or drug reactions. Taken together with clinical findings, the microscopic features from skin biopsy can allow recognition of various patterns and facilitate a precise diagnosis. Accurate classification of entities in this category of inflammatory dermatoses may prompt clinicians to investigate for underlying systemic problems, thereby allowing the pathologist to add considerable value in the care of affected patients. This review article categorizes clinical and microscopic features of common and uncommon causes of noninfectious dermal and subcutaneous granulomatous inflammation.

Original languageEnglish (US)
Pages (from-to)127-145
Number of pages19
JournalHuman Pathology
StatePublished - Sep 2020


  • Dermatopathology
  • Granuloma
  • Histiocytes
  • Histopathology
  • Infection
  • Sarcoidosis
  • Skin

ASJC Scopus subject areas

  • Pathology and Forensic Medicine


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