Histone chaperones in nucleosome assembly and human disease

Rebecca J. Burgess, Zhiguo Zhang

Research output: Contribution to journalReview articlepeer-review

215 Scopus citations


Nucleosome assembly following DNA replication, DNA repair and gene transcription is critical for the maintenance of genome stability and epigenetic information. Nucleosomes are assembled by replication-coupled or replication-independent pathways with the aid of histone chaperone proteins. How these different nucleosome assembly pathways are regulated remains relatively unclear. Recent studies have provided insight into the mechanisms and the roles of histone chaperones in regulating nucleosome assembly. Alterations or mutations in factors involved in nucleosome assembly have also been implicated in cancer and other human diseases. This review highlights the recent progress and outlines future challenges in the field.

Original languageEnglish (US)
Pages (from-to)14-22
Number of pages9
JournalNature Structural and Molecular Biology
Issue number1
StatePublished - Jan 2013

ASJC Scopus subject areas

  • Structural Biology
  • Molecular Biology


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