Histologic remission of cardiac amyloidosis: A case report

Matthew R. Nelson, Louis A. Lanza, Craig B. Reeder, Robert L. Scott, Ann E. McCullough, Krishnaswamy Chandrasekaran, Roger L. Click

Research output: Contribution to journalArticlepeer-review

4 Scopus citations


The main determinant of survival in amyloid light chain amyloidosis is cardiac involvement. The rate of change in wall thickness may be a strong predictor of survival. After treatment, some hematologic responders have had documented regression of wall thickness by echocardiography with resolution of heart failure symptoms. Herein, we demonstrate a case of treated immunoglobulin light chain cardiac amyloidosis with echocardiographic wall thinning and cardiac biopsies demonstrating complete histologic remission. This observation suggests a mechanism of treatment response and that with appropriately timed treatment, cardiac deposition of amyloid fibrils can be completely reversed.

Original languageEnglish (US)
Pages (from-to)106-109
Number of pages4
Issue number2
StatePublished - Jun 1 2012


  • Biopsy
  • Cardiac amyloid
  • Echocardiography
  • Histologic regression

ASJC Scopus subject areas

  • Internal Medicine


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