Histologic evaluation of platinum coil embolization in an aneurysm model in rabbits

David F. Kallmes, Gregory A. Helm, Sarah B. Hudson, Talissa A. Altes, Huy M. Do, James W. Mandell, Harry J. Cloft

Research output: Contribution to journalArticlepeer-review

88 Scopus citations


PURPOSE: To characterize the histologic response to platinum coil embolization by using a rabbit aneurysm model. MATERIALS AND METHODS: Saccular aneurysms were created in New Zealand White rabbits by using vessel ligation with intraluminal elastase incubation. Aneurysms were subsequently embolized by using platinum coils. Subjects were sacrificed at various intervals up to 12 weeks following coil embolization. The aneurysm cavities and adjacent vessels were embedded in methylmethacrylate, were sectioned, and were stained for histologic examination. RESULTS: Two weeks following coil implantation, aneurysms were filled predominantly with unorganized thrombus. Six weeks following coil implantation, histologic features included complete filling of the aneurysm lumen with either prominent laminated but unorganized thrombus or areas of unorganized thrombus interspersed among areas of cellular infiltration. At 12 weeks following coil implantation, aneurysms were filled with the loosely packed, disordered cells contained within the extracellular matrix. Fibrosis or smooth muscle cell infiltration was not present in any of the 6- or 12-week samples. CONCLUSION: Platinum coils placed into experimental saccular aneurysms in New Zealand White rabbits failed to elicit a fibrotic response. This model can be used for the testing of biologic modifications of platinum coils aimed at increasing intra- aneurysmal fibrosis.

Original languageEnglish (US)
Pages (from-to)217-222
Number of pages6
Issue number1
StatePublished - Oct 1999


  • Aneurysm, carotid
  • Aneurysm, therapy
  • Carotid arteries, therapeutic blockade

ASJC Scopus subject areas

  • Radiology Nuclear Medicine and imaging


Dive into the research topics of 'Histologic evaluation of platinum coil embolization in an aneurysm model in rabbits'. Together they form a unique fingerprint.

Cite this