Histiocytes containing immunoglobulin crystals in the urine of a patient with IgA κ plasmacytoma of the bladder

Dylan V. Miller, Rebecca F. McClure, Barbara G. Crawford, Steven R. Zeldenrust, Bradley C. Leibovich, Thomas J. Sebo

Research output: Contribution to journalArticlepeer-review

3 Scopus citations


Exfoliative cytology specimens from patients with plasma cell dyscrasias are rarely diagnostic, though there are reports of neoplastic plasma cells observed in pleural fluid and urine. Immunoglobulin concretions or crystals associated with neoplastic plasma cell populations have been well described. These crystals may be found within plasma cell nuclei or cytoplasm, extracellularly, or within cells of histiocytic lineage where they are presumably derived by phagocytosis. To the best of our knowledge, this is the first report of immunoglobulin crystals within histiocytes in the urine of a patient with plasmacytoma. A 61-year-old male underwent routine cystoscopy and urine collection to evaluate hematuria. The bladder biopsy demonstrated IgA κ-producing plasmacytoma. Urine cytopsin preparations did not contain plasma cells, but there were histiocytic cells with degenerative nuclei and eccentrically located cytoplasmic spherical refractile hyaline crystals thought to be immunoglobulin crystals. This was supported by immunocytochemical staining.

Original languageEnglish (US)
Pages (from-to)48-51
Number of pages4
JournalDiagnostic cytopathology
Issue number1
StatePublished - Jul 2004


  • Exfoliative cytology
  • Immunoglobulin crystals
  • Plasmocytic neoplasia
  • Urine

ASJC Scopus subject areas

  • Pathology and Forensic Medicine
  • Histology


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