Anormalidades neuroendocrinas en el síndrome de poliquistosis ov́rica

Translated title of the contribution: Highlights on the neuroendocrine adaptation in polycistic ovarian syndrome

M. C. García Rudaz, J. D. Veldhuis, M. B. Barontini

Research output: Contribution to journalReview articlepeer-review


Polycystic ovarian disease (PCO) is the most common primary reproductive abnormality associated with impaired fertility in young women. This syndrome is hallmarked by hypersecretion of luteinizing hormone (LH), ovarian theca-cell hypertrophy, hyperandrogenemia, oligo- or anovulation, amenorrhea, hyperinsulinism, dyslipidermia and increased cardiovascular risk. Within this constellation, cardinal pathophysiological features are hyperinsulinism and excessive LH secretion. At least four categories of insulin-depleting regimens are able to improve or normalize various facets of reproductive impairment in PCO. However, the mechanistic bases of LH hypersecretion and insulin resistance, and the manner (if any) whereby the foregoing major pathophysiologies are causally interlinked are unknown.

Translated title of the contributionHighlights on the neuroendocrine adaptation in polycistic ovarian syndrome
Original languageSpanish
Pages (from-to)113-124
Number of pages12
JournalCuadernos de Medicina Reproductiva
Issue number1
StatePublished - Jan 1 2003

ASJC Scopus subject areas

  • Obstetrics and Gynecology


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