Higher temporal resolution multiband fMRI provides improved presurgical language maps

Ian T. Mark, David F. Black, David R. DeLone, Theodore J. Passe, Robert J. Witte, Jason T. Little, Mai Lan Ho, Andrew J. Fagan, Ian F. Parney, Terence C. Burns, Kirk M. Welker

Research output: Contribution to journalArticlepeer-review


Purpose: We investigated the hypothesis that increasing fMRI temporal resolution using a multiband (MB) gradient echo-echo planar imaging (GRE-EPI) pulse sequence provides fMRI language maps of higher statistical quality than those acquired with a traditional GRE-EPI sequence. Methods: This prospective study enrolled 29 consecutive patients receiving language fMRI prior to a potential brain resection for tumor, AVM, or epilepsy. A 4-min rhyming task was performed at 3.0 Tesla with a traditional GRE-EPI pulse sequence (TR = 2000, TE = 30, matrix = 64/100%, slice = 4/0, FOV = 24, slices = 30, time points = 120) and an additional MB GRE-EPI pulse sequence with an acceleration factor of 6 (TR = 333, TE = 30, matrix 64/100%, slice = 4/0, FOV = 24, time points = 720). Spatially filtered t statistical maps were generated. Volumes of interest (VOIs) were drawn around activations at Broca’s, dorsolateral prefrontal cortex, Wernicke’s, and the visual word form areas. The t value maxima were measured for the overall brain and each of the VOIs. A paired t test was performed for the corresponding traditional and MB GRE-EPI measurements. Results: The mean age of subjects was 42.6 years old (18–75). Sixty-two percent were male. The average overall brain t statistic maxima for the MB pulse sequence (t = 15.4) was higher than for the traditional pulse sequence (t = 9.3, p = <.0001). This also held true for Broca’s area (p < 0.0001), Wernicke’s area (p <.0001), dorsolateral prefrontal cortex (p <.0001), and the visual word form area (p <.0001). Conclusion: A MB GRE-EPI fMRI pulse sequence employing high temporal resolution provides clinical fMRI language maps of greater statistical significance than those obtained with a traditional GRE-EPI sequence.

Original languageEnglish (US)
Pages (from-to)439-445
Number of pages7
Issue number3
StatePublished - Mar 2021


  • Functional MRI
  • Language maps
  • Multiband pulse sequences

ASJC Scopus subject areas

  • Radiology Nuclear Medicine and imaging
  • Clinical Neurology
  • Cardiology and Cardiovascular Medicine


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