@article{97ae5d0cf1724abdbe7d4e0b07322088,
title = "Higher order genomic organization and epigenetic control maintain cellular identity and prevent breast cancer",
abstract = "Cells establish and sustain structural and functional integrity of the genome to support cellular identity and prevent malignant transformation. In this review, we present a strategic overview of epigenetic regulatory mechanisms including histone modifications and higher order chromatin organization (HCO) that are perturbed in breast cancer onset and progression. Implications for dysfunctions that occur in hormone regulation, cell cycle control, and mitotic bookmarking in breast cancer are considered, with an emphasis on epithelial-to-mesenchymal transition and cancer stem cell activities. The architectural organization of regulatory machinery is addressed within the contexts of translating cancer-compromised genomic organization to advances in breast cancer risk assessment, diagnosis, prognosis, and identification of novel therapeutic targets with high specificity and minimal off target effects.",
keywords = "RUNX, breast cancer, cancer stem cells, epithelial to mesenchymal transition, higher order chromatin organization, hormone regulation, mitotic bookmarking",
author = "Fritz, {A. J.} and Gillis, {N. E.} and Gerrard, {D. L.} and Rodriguez, {P. D.} and D. Hong and Rose, {J. T.} and Ghule, {P. N.} and Bolf, {E. L.} and Gordon, {J. A.} and Tye, {C. E.} and Boyd, {J. R.} and Tracy, {K. M.} and Nickerson, {J. A.} and {van Wijnen}, {A. J.} and Imbalzano, {A. N.} and Heath, {J. L.} and Frietze, {S. E.} and Zaidi, {S. K.} and Carr, {F. E.} and Lian, {J. B.} and Stein, {J. L.} and Stein, {G. S.}",
note = "Funding Information: American Cancer Society, Grant/Award Numbers: 033807, 14-196-01; National Cancer Institute, Grant/Award Numbers: 1F32 CA220935, P01 CA082834, U01 CA196383, 1F32CA236125, 1U54CA217297; National Institute of Dental and Craniofacial Research, Grant/Award Number: R56 DE012528; Charlotte Perelman Fund for Cancer Research; Pediatric Cancer Research Foundation; National Institute of General Medical Sciences, Grant/Award Number: R01GM129338 Funding Information: This work was supported by National Institutes of Health grants NCI P01 CA082834 (G.S.S., J.L.S.), R37 DE012528 (J.B.L.), NCI 1F32 CA220935 (A.J.F.), U01 CA196383 (J.L.S), 1U54 CA217297 (S.F.), NIGMS R01 GM129338 (S.F.). the Charlotte Perelman Fund for Cancer Research (G.S.S.) and an Institutional Research Grant (14-196-01) from the American Cancer Society (project# 033807) to PNG, and the Pediatric Cancer Research Foundation (J.H.). Publisher Copyright: {\textcopyright} 2019 Wiley Periodicals, Inc.",
year = "2019",
month = jul,
doi = "10.1002/gcc.22731",
language = "English (US)",
volume = "58",
pages = "484--499",
journal = "Genes Chromosomes and Cancer",
issn = "1045-2257",
publisher = "Wiley-Liss Inc.",
number = "7",
}