High sensitivity C-reactive protein: A novel predictor for recurrence of atrial fibrillation after successful cardioversion

Joseph F. Malouf, Ravi Kanagala, Faisal O. Al Atawi, A. Gabriela Rosales, Diane E. Davison, Narayana S. Murali, Teresa S.M. Tsang, Krishnaswamy Chandrasekaran, Naser M. Ammash, Paul A. Friedman, Virend K. Somers

Research output: Contribution to journalArticlepeer-review

101 Scopus citations


OBJECTIVES: We sought to test the hypothesis that C-reactive protein (CRP) can predict the recurrence of atrial fibrillation (AF) after successful electrical cardioversion (CV). BACKGROUND: In patients with AF, CRP levels are predictive of immediate failure of CV. METHODS: We prospectively measured high-sensitivity CRP in 67 patients with AF or atrial flutter who underwent successful electrical CV. RESULTS: At one-month follow-up, 22 patients (33%) had recurrence of their arrhythmia. Arrhythmia recurrence was associated with significantly higher pre-CV CRP levels (odds ratio [OR] 1.84; 95% confidence interval [CI] 1.14 to 2.98; p = 0.013) even after adjusting for age (OR 2.22; 95% CI 1.25 to 3.93; p = 0.006), for gender (OR 1.89; 95% CI 1.16 to 3.09; p = 0.011), or duration of arrhythmia (OR 1.86; 95% CI 1.13 to 3.07; p = 0.015). On multivariate analysis, CRP was the only independent predictor of arrhythmia recurrence (OR 2.19; 95% CI 1.05 to 4.55; p = 0.036). CONCLUSIONS: Our data suggest that high levels of CRP are associated with an increased risk of recurrence of AF within one month. These data support the hypothesis that anti-inflammatory interventions may help in maintenance of normal sinus rhythm after CV. These data also may have implications for the identification of patients who are most likely to experience substantial benefit from CV therapy for AF.

Original languageEnglish (US)
Pages (from-to)1284-1287
Number of pages4
JournalJournal of the American College of Cardiology
Issue number7
StatePublished - Oct 4 2005

ASJC Scopus subject areas

  • Cardiology and Cardiovascular Medicine


Dive into the research topics of 'High sensitivity C-reactive protein: A novel predictor for recurrence of atrial fibrillation after successful cardioversion'. Together they form a unique fingerprint.

Cite this