High-risk prostate cancer: The role of surgical management

Alessandro Morlacco, Robert Jeffrey Karnes

Research output: Contribution to journalArticlepeer-review

11 Scopus citations


High-risk prostate cancer (HR Pca) is a highly heterogeneous disease from a biological and clinical standpoint, and it carries a significant chance of morbidity and mortality. Despite the impact of PSA screening, a significant number of men continue to present with high risk disease and need adequate management: clinical evidence shows that a considerable fraction on men with HR PCa can be actually cured with either uni- or multi-modality approaches. Surgical treatment, once considered unfeasible in this setting, is acquiring more and more diffusion in modern clinical practice. Herein we discuss the main treatment strategies for high-risk prostate cancer, providing an expert opinion on the role of surgical management and its outcomes in the most recent literature.

Original languageEnglish (US)
Pages (from-to)135-143
Number of pages9
JournalCritical Reviews in Oncology/Hematology
StatePublished - Jun 1 2016


  • High risk
  • Prostate cancer
  • Prostate surgery
  • Radiation therapy
  • Radical prostatectomy

ASJC Scopus subject areas

  • Oncology
  • Hematology
  • Geriatrics and Gerontology


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