TY - JOUR
T1 - High-risk echocardiographic features predict mortality in pulmonary arterial hypertension
AU - Austin, Christopher
AU - Burger, Charles
AU - Kane, Garvan
AU - Safford, Robert
AU - Blackshear, Joseph
AU - Ung, Ryan
AU - Ray, Jordan
AU - Alsaad, Ali
AU - Alassas, Khadija
AU - Shapiro, Brian
N1 - Publisher Copyright:
© 2017 Elsevier Inc.
PY - 2017/7/1
Y1 - 2017/7/1
N2 - Aims Echocardiography is the most common imaging modality for assessment of the right ventricle in patients with pulmonary arterial hypertension (PAH). Echocardiographic parameters were identified as independent risk factors for mortality in the Registry to Evaluate Early and Long-term PAH Disease Management (REVEAL) and other PAH cohorts. We sought to identify readily obtained echocardiographic features associated with PAH survival. Methods and results Retrospective analysis of 175 patients with Group 1 was performed. Baseline clinical and laboratory assessment including REVEAL risk criteria were obtained and standard 2-Dimensional and Doppler echocardiography performed at baseline was reviewed. Univariate and multivariate analyses of echocardiographic parameters were performed. Estimated right atrial pressure> 15 mmHg (HR 2.39, P =.02), tricuspid regurgitation ≥ moderate (HR 2.16, P =.04), and presence of pericardial effusion (HR 1.8, P =.05) were identified as independent, high-risk echocardiographic features in PAH. A validation cohort of 677 patients was identified and Kaplan–Meier survival analysis was performed in both cohorts. High-risk echocardiographic features stratified survival curves of both cohorts (P <.01 for all). The presence of 3 high-risk echocardiographic features greatly increased risk of 1-year (RR 4.86) and 3-year (RR 3.35) mortality (P <.05 for both). Conclusion Estimated right atrial pressure> 15, tricuspid regurgitation ≥ moderate, and presence of pericardial effusion are high-risk echocardiographic features in PAH. When seen in combination, these features greatly increase risk of mortality in PAH and may lead to more timely enhanced therapy for patients identified as having an increased risk for death.
AB - Aims Echocardiography is the most common imaging modality for assessment of the right ventricle in patients with pulmonary arterial hypertension (PAH). Echocardiographic parameters were identified as independent risk factors for mortality in the Registry to Evaluate Early and Long-term PAH Disease Management (REVEAL) and other PAH cohorts. We sought to identify readily obtained echocardiographic features associated with PAH survival. Methods and results Retrospective analysis of 175 patients with Group 1 was performed. Baseline clinical and laboratory assessment including REVEAL risk criteria were obtained and standard 2-Dimensional and Doppler echocardiography performed at baseline was reviewed. Univariate and multivariate analyses of echocardiographic parameters were performed. Estimated right atrial pressure> 15 mmHg (HR 2.39, P =.02), tricuspid regurgitation ≥ moderate (HR 2.16, P =.04), and presence of pericardial effusion (HR 1.8, P =.05) were identified as independent, high-risk echocardiographic features in PAH. A validation cohort of 677 patients was identified and Kaplan–Meier survival analysis was performed in both cohorts. High-risk echocardiographic features stratified survival curves of both cohorts (P <.01 for all). The presence of 3 high-risk echocardiographic features greatly increased risk of 1-year (RR 4.86) and 3-year (RR 3.35) mortality (P <.05 for both). Conclusion Estimated right atrial pressure> 15, tricuspid regurgitation ≥ moderate, and presence of pericardial effusion are high-risk echocardiographic features in PAH. When seen in combination, these features greatly increase risk of mortality in PAH and may lead to more timely enhanced therapy for patients identified as having an increased risk for death.
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U2 - 10.1016/j.ahj.2017.04.013
DO - 10.1016/j.ahj.2017.04.013
M3 - Article
C2 - 28625373
AN - SCOPUS:85019168497
SN - 0002-8703
VL - 189
SP - 167
EP - 176
JO - American heart journal
JF - American heart journal
ER -