TY - JOUR
T1 - High-risk adverse drug reactions
T2 - consideration of limited dialysis therapy for toxic epidermal necrolysis (TEN)
AU - Xie, Guozhen
AU - Pincelli, Thais
AU - Hickson, La Tonya J.
AU - el-Azhary, Rokea
AU - Sokumbi, Olayemi
N1 - Publisher Copyright:
© 2023 the International Society of Dermatology.
PY - 2024/1
Y1 - 2024/1
N2 - Toxic epidermal necrolysis (TEN) is a rare but often lethal drug reaction involving the skin. Treatment is often centered around suppurative care, and the mortality rate remains unacceptably high, although the clinical and epidemiological features of TEN have been well documented for decades. Recent studies have placed an emphasis on certain medications in the pathophysiology of severe TEN, and our colleagues previously reported several cases of clinical improvement in TEN patients following hemodialysis. Here, we discuss the major considerations for initiating dialysis in TEN patients. By doing so, we hope to encourage others to explore this potential avenue for treating TEN, one of the most serious medical emergencies in the field of dermatology.
AB - Toxic epidermal necrolysis (TEN) is a rare but often lethal drug reaction involving the skin. Treatment is often centered around suppurative care, and the mortality rate remains unacceptably high, although the clinical and epidemiological features of TEN have been well documented for decades. Recent studies have placed an emphasis on certain medications in the pathophysiology of severe TEN, and our colleagues previously reported several cases of clinical improvement in TEN patients following hemodialysis. Here, we discuss the major considerations for initiating dialysis in TEN patients. By doing so, we hope to encourage others to explore this potential avenue for treating TEN, one of the most serious medical emergencies in the field of dermatology.
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U2 - 10.1111/ijd.16882
DO - 10.1111/ijd.16882
M3 - Article
C2 - 37888765
AN - SCOPUS:85175014357
SN - 0011-9059
VL - 63
SP - 5
EP - 9
JO - International journal of dermatology
JF - International journal of dermatology
IS - 1
ER -