High-resolution intracranial and cervical MRA at 3.0T: Technical considerations and initial experience

Matt A. Bernstein, John Huston, Chen Lin, Gordon F. Gibbs, Joel P. Felmlee

Research output: Contribution to journalArticlepeer-review

186 Scopus citations


Initial experience with intracranial and cervical MRA at 3.0T is reported. Phantom measurements (corrected for relaxation effects) show S/N (3.0T) = 2.14 ± 0.08 × S/N (1.5T) in identical-geometry head coils. A 3.0T 3DTOF intracranial imaging protocol with higher-order autoshimming was developed and compared to 1.5T 3DTOF in 12 patients with aneurysms. A comparison by two radiologists showed the 3.0T to be significantly better (P < 0.001) for visualization of the aneurysms. The feasibility of cervical and intracranial contrast enhanced MR angiography (CEMRA) at 3.0T is also examined. The relaxivity of the gadolinium contrast agent decreases by only about 4-7% when the field strength is increased from 1.5 to 3.0T. Cervical 3.0T CEMRA was obtained in eight patients, two of whom had 1.5T studies available for direct comparison. Image comparison suggests 3.0T to be a favorable field strength for cervical CEMRA. Voxel volumes of 0.62-0.73 mm3 (not including zero-filling) were readily achieved at 3.0T with the use of a single-channel transmit-receive head or cervical coil, a 25 mL bolus of gadoteridol, and a 3D pulse sequence with a 66% sampling efficiency. This spatial resolution allowed visualization of intracranial aneurysms, carotid dissections, and atherosclerotic disease including ulcerations. Potential drawbacks of 3.0T MRA are increased SAR and T*2dephasing compared to 1.5T. Image comparison suggests signal loss due to T*2dephasing will not be substantially more problematic than at 1.5T. The dependence of RF power deposition on TR for CEMRA is calculated and discussed.

Original languageEnglish (US)
Pages (from-to)955-962
Number of pages8
JournalMagnetic Resonance in Medicine
Issue number5
StatePublished - 2001


  • 3T
  • Contrast enhanced MRA
  • High field

ASJC Scopus subject areas

  • Radiology Nuclear Medicine and imaging


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