TY - JOUR
T1 - High rate of aminoglycoside resistance among staphylococci causing prosthetic joint infection
AU - Anguita-Alonso, Paloma
AU - Hanssen, Arlen D.
AU - Osmon, Douglas R.
AU - Trampuz, Andrej
AU - Steckelberg, James M.
AU - Patel, Robin
PY - 2005/10
Y1 - 2005/10
N2 - Gentamicin and tobramycin are two aminoglycosides commonly impregnated into polymethylmethacrylate for treatment and prevention of prosthetic joint infection. Susceptibilities of staphylococci to aminoglycosides are not reported routinely in the United States. The gentamicin and tobramycin minimum inhibitory value of 93 staphylococci from patients with PJI were determined. Forty-one and 66% of the isolates were resistant to gentamicin and tobramycin, respectively. Methicillin-resistant Staphylococcus aureus isolates were more likely to be resistant to gentamicin or tobramycin than were their methicillin susceptible counterparts. The findings suggest that consideration should be given to the further study of agents other than aminoglycosides for incorporation into polymethylmethacrylate for the treatment and prevention of prosthetic joint infection.
AB - Gentamicin and tobramycin are two aminoglycosides commonly impregnated into polymethylmethacrylate for treatment and prevention of prosthetic joint infection. Susceptibilities of staphylococci to aminoglycosides are not reported routinely in the United States. The gentamicin and tobramycin minimum inhibitory value of 93 staphylococci from patients with PJI were determined. Forty-one and 66% of the isolates were resistant to gentamicin and tobramycin, respectively. Methicillin-resistant Staphylococcus aureus isolates were more likely to be resistant to gentamicin or tobramycin than were their methicillin susceptible counterparts. The findings suggest that consideration should be given to the further study of agents other than aminoglycosides for incorporation into polymethylmethacrylate for the treatment and prevention of prosthetic joint infection.
UR - http://www.scopus.com/inward/record.url?scp=26244468777&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=26244468777&partnerID=8YFLogxK
U2 - 10.1097/01.blo.0000182394.39601.9d
DO - 10.1097/01.blo.0000182394.39601.9d
M3 - Article
C2 - 16205136
AN - SCOPUS:26244468777
SN - 0009-921X
VL - 439
SP - 43
EP - 47
JO - Clinical orthopaedics and related research
JF - Clinical orthopaedics and related research
ER -