TY - JOUR
T1 - High-quality nuclear genome for sarcoptes Scabiei—A critical resource for a neglected parasite
AU - Korhonen, Pasi K.
AU - Gasser, Robin B.
AU - Ma, Guangxu
AU - Wang, Tao
AU - Stroehlein, Andreas J.
AU - Young, Neil D.
AU - Ang, Ching Seng
AU - Fernando, Deepani D.
AU - Lu, Hieng C.
AU - Taylor, Sara
AU - Reynolds, Simone L.
AU - Mofiz, Ehtesham
AU - Najaraj, Shivashankar H.
AU - Gowda, Harsha
AU - Madugundu, Anil
AU - Renuse, Santosh
AU - Holt, Deborah
AU - Pandey, Akhilesh
AU - Papenfuss, Anthony T.
AU - Fischer, Katja
N1 - Funding Information:
Funding:SupportfromtheAustralianResearch Council(ARC)andtheNationalHealthandMedical ResearchCouncil(NHMRC)ofAustraliais gratefullyacknowledged(K.F,R.B.G.,N.D.Y.andP. K.K).K.F.heldanARCFutureFellowshipfollowed byanNHMRCSeniorResearchFellowshipand.P. K.K.heldanNHMRCEarlyCareerResearch Fellowship.Thefundershadnoroleinstudy design,datacollectionandanalysis,decisionto publish,orpreparationofthemanuscript.
Funding Information:
Support from the Australian Research Council (ARC) and the National Health and Medical Research Council (NHMRC) of Australia is gratefully acknowledged (K.F, R.B.G., N.D.Y. and P. K.K). K.F. held an ARC Future Fellowship followed by an NHMRC Senior Research Fellowship and. P. K.K. held an NHMRC Early Career Research Fellowship. The funders had no role in study design, data collection and analysis, decision to publish, or preparation of the manuscript. The authors thank Milou Dekkers, Scott Cullen and Sheree Boisen at at the Queensland Animal Science Precinct, University of Queensland, Gatton Campus, Australia, for maintainingS. scabiei on pigs. The authors thank Dr Lawrie Wheeler for PacBio sequencing.
Publisher Copyright:
© 2020 Korhonen et al.
PY - 2020/10
Y1 - 2020/10
N2 - The parasitic mite Sarcoptes scabiei is an economically highly significant parasite of the skin of humans and animals worldwide. In humans, this mite causes a neglected tropical disease (NTD), called scabies. This disease results in major morbidity, disability, stigma and poverty globally and is often associated with secondary bacterial infections. Currently, anti-scabies treatments are not sufficiently effective, resistance to them is emerging and no vaccine is available. Here, we report the first high-quality genome and transcriptomic data for S. scabiei. The genome is 56.6 Mb in size, has a a repeat content of 10.6% and codes for 9,174 proteins. We explored key molecules involved in development, reproduction, host-parasite interactions, immunity and disease. The enhanced ‘omic data sets for S. scabiei represent comprehensive and critical resources for genetic, functional genomic, metabolo-mic, phylogenetic, ecological and/or epidemiological investigations, and will underpin the design and development of new treatments, vaccines and/or diagnostic tests.
AB - The parasitic mite Sarcoptes scabiei is an economically highly significant parasite of the skin of humans and animals worldwide. In humans, this mite causes a neglected tropical disease (NTD), called scabies. This disease results in major morbidity, disability, stigma and poverty globally and is often associated with secondary bacterial infections. Currently, anti-scabies treatments are not sufficiently effective, resistance to them is emerging and no vaccine is available. Here, we report the first high-quality genome and transcriptomic data for S. scabiei. The genome is 56.6 Mb in size, has a a repeat content of 10.6% and codes for 9,174 proteins. We explored key molecules involved in development, reproduction, host-parasite interactions, immunity and disease. The enhanced ‘omic data sets for S. scabiei represent comprehensive and critical resources for genetic, functional genomic, metabolo-mic, phylogenetic, ecological and/or epidemiological investigations, and will underpin the design and development of new treatments, vaccines and/or diagnostic tests.
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U2 - 10.1371/journal.pntd.0008720
DO - 10.1371/journal.pntd.0008720
M3 - Article
C2 - 33001992
AN - SCOPUS:85094933450
SN - 1935-2727
VL - 14
SP - 1
EP - 20
JO - PLoS Neglected Tropical Diseases
JF - PLoS Neglected Tropical Diseases
IS - 10
M1 - e0008720
ER -