High-frequency oscillations and other electrophysiological biomarkers of epilepsy: Clinical studies

Greg Worrell, Jean Gotman

Research output: Contribution to journalReview articlepeer-review

75 Scopus citations


Accurate localization of epileptogenic brain is critical for successful epilepsy surgery. Recent research using wide bandwidth intracranial EEG has demonstrated that interictal high-frequency oscillations are preferentially localized to the brain region generating spontaneous seizures, and are a potential biomarker of epileptogenic brain. The existence of an interictal, electrophysiological biomarker of epileptogenic brain has the potential to significantly advance epilepsy surgery by improving outcomes through improved localization and potentially eliminating the reliance on chronic intracranial EEG monitoring.

Original languageEnglish (US)
Pages (from-to)557-566
Number of pages10
JournalBiomarkers in Medicine
Issue number5
StatePublished - Oct 2011


  • epilepsy surgery
  • epileptogenic zone
  • fast ripple
  • high-frequency oscillation
  • ripple
  • seizure onset zone
  • wide bandwidth EEG

ASJC Scopus subject areas

  • Drug Discovery
  • Clinical Biochemistry
  • Biochemistry, medical


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